Helicobacter Pylori eradication increases telomere length in gastric mucosa

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dc.contributor.authorAslan R.
dc.contributor.authorBektas A.
dc.contributor.authorBedir A.
dc.contributor.authorAlacam H.
dc.contributor.authorAslan M.S.
dc.contributor.authorNar R.
dc.contributor.authorOkuyucu A.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractBackground/Aims: Our purpose in this study was to analyze telomere length and telomerase activity before and after eradication treatment in gastric mucosa in patients positive for H. pylori. Methodology: There were two groups: a control group (n=17) and a study group (n=21). For H. pylori eradication, the patients were administrated proton pump inhibitor (PPI) + clarithromycin + amoxicillin or PPI + metronidazole + tetracycline + bismuth for 14 days. Telomere length was analyzed with RT-PCR and telomerase activity with PCR-ELISA on biopsy specimens from the antrum. The result p<0.05 was considered significant. Results: Prior to eradication, there was no significant difference between telomere lengths of the patient and control groups (2481.2±1823 and 2958.9±1345.7 bp, p=0.11, respectively). The telomere length of the study group became longer after eradication (before 2481.2±1823bp, after 3766.3±1608.8bp, p=0.01). Telomerase activity was not detected in either the patient or the control group. Conclusions: An increase in telomere length was observed with H. pylori eradication. This finding may indicate the importance of H. pylori eradication to avoid the development of gastric cancer. © H.G.E. Update Medical Publishing S.A.
dc.identifier.doi10.5754/hge12691
dc.identifier.endpage604
dc.identifier.issn0172-6390
dc.identifier.issue123
dc.identifier.pmid23108080
dc.identifier.startpage601
dc.identifier.urihttps://dx.doi.org/10.5754/hge12691
dc.identifier.urihttps://hdl.handle.net/11480/832
dc.identifier.volume60
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHelicobacter pylori
dc.subjectPCR-ELISA
dc.subjectRT-PCR
dc.subjectTelomerase activity
dc.subjectTelomere length
dc.titleHelicobacter Pylori eradication increases telomere length in gastric mucosa
dc.typeArticle

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