THE RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND EARLY MORTALITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE CASES DURING EXACERBATION

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dc.contributor.authorBuyukbayram, Gokban
dc.contributor.authorYuceer, Omer
dc.contributor.authorOymak, Fatma Sema
dc.date.accessioned2024-11-07T13:34:06Z
dc.date.available2024-11-07T13:34:06Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: In this study, it was aimed to compare the levels of serum uric acid and uric acid/creatinine ratios in patients with COPD during an attack or in stable COPD, and to show whether serum uric acid and uric acid/creatinine ratios are associated with early mortality in COPD patients during an acute attack. Materials and Methods: In this study, COPD acute attack (n=155) and stable COPD (n=30) patients were evaluated. The data of these patients were obtained from patient files and computer records. COPD diagnosis and severity assessment were made according to the GOLD 2006 guideline. Participants??? age, gender, body mass index, pulmonary function test, arterial blood gas, uric acid, creatinine values and comorbidity information were recorded in the previously prepared Case Data Form. In 2012, when we conducted this study, gold 2006 was taken as the guideline for spirometry measurement, but spirometric measurements determined with reference values determined according to age, height and gender, and FEV1/FVC measurement <70% as diagnostic criteria in acute attack after bronchodilator were the guidelines used later, gold 2017. It is also compatible with gold2020 and gold2021 spirometry criteria. Results: It was determined that the uric acid (p 0.001) and uric acid/creatinine (p??0.001) levels of the patients in the acute attack group were significantly higher than the levels of the patients in the stable group. The attack group was divided into two subgroups according to certain cut-off points for uric acid ( 6 mg/dl for women and >7 mg/dl for men) and uric acid/ creatinine ratio (median value 7.10). Since the upper limit of the uric acid value measured in the blood is 6 mg/dl in women and 7-8 mg/dl in men, the cut-off points for uric acid (>6 mg/dl for women and >7 mg/dl for men) were determined in our study. According to this categorization, it was determined that there was no statistically significant relationship between uric acid level (odds ratio 2.985 [95% confidence interval 0.61814,151]) and early mortality risk. Conclusion: The results of this study showed that the uric acid and uric acid/ creatinine levels in the attack group were higher than the levels in the stable group, but these parameters were not associated with early mortality.
dc.identifier.doi10.36141/svdld.v39i2.12127
dc.identifier.issn1124-0490
dc.identifier.issue2
dc.identifier.pmid36118541
dc.identifier.urihttps://doi.org/10.36141/svdld.v39i2.12127
dc.identifier.urihttps://hdl.handle.net/11480/15799
dc.identifier.volume39
dc.identifier.wosWOS:000822189300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMattioli 1885
dc.relation.ispartofSarcoidosis Vasculitis and Diffuse Lung Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectchronic obstructive pulmonary disease
dc.subjecturic acid
dc.subjecturic acid
dc.subjectcreatinine ratio
dc.subjectmortality
dc.titleTHE RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND EARLY MORTALITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE CASES DURING EXACERBATION
dc.typeArticle

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