Role of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats

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dc.authorid0000-0001-6080-229X
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGok, Yetkin
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2010
dc.departmentNiğde ÖHÜ
dc.description.abstractSynthetic organoselenium compounds can be tailored to achieve greater chemopreventive efficacy with minimal toxic side effects by structural modifications. Two organoselenium compounds (Se I and Se II) were synthesized and evaluated for their antihypertensive and therapeutic properties by adrenomedullin (ADM) levels and tyrosine hydroxylase (TH) activity assays in rat heart tissue. 7,12-Dimethylbenz[a]anthracene (DMBA) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. TH is thought to be a rate-limiting enzyme in the biosynthesis of catecholamines. ADM, a potent endogenous vasodilating and natriuretic peptide, may play an important role in the pathophysiology of chronic heart failure. The effects of Se I and Se II were investigated on TH activity, ADM and total RNA levels in the hearts of albino Wistar rats. TH activity was found to be increased significantly by the effect of DMBA (P < 0.05). This increase was restricted in the Se I and Se H treated groups. ADM level was found to be decreased insignificantly by the effect of DMBA (P > 0.05). Total RNA level was found to be decreased significantly by the effect of DMBA (P < 0.05). This study demonstrates that synthetic organoselenium compounds can regulate DMBA-induced stress related changes in rat heart. (C) 2009 Elsevier B.V. All rights reserved.
dc.description.sponsorshipInonu University [BAP 2005/60]
dc.description.sponsorshipInonu University Research Fund (BAP 2005/60) is gratefully acknowledged for support of this work.
dc.identifier.doi10.1016/j.regpep.2009.08.009
dc.identifier.endpage141
dc.identifier.issn0167-0115
dc.identifier.issn1873-1686
dc.identifier.issue45352
dc.identifier.pmid19706312
dc.identifier.scopus2-s2.0-71349085372
dc.identifier.scopusqualityN/A
dc.identifier.startpage137
dc.identifier.urihttps://dx.doi.org/10.1016/j.regpep.2009.08.009
dc.identifier.urihttps://hdl.handle.net/11480/4921
dc.identifier.volume159
dc.identifier.wosWOS:000273920500021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofREGULATORY PEPTIDES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTyrosine hydroxylase
dc.subjectAdrenomedullin
dc.subjectHeart
dc.subjectOrganoselenium compounds
dc.subjectRat
dc.titleRole of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats
dc.typeArticle

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