The effects of acrylamide and vitamin E on kidneys in pregnancy: an experimental study

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridTurkoz, Yusuf/0000-0001-5401-0720
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-11-07T13:32:35Z
dc.date.available2024-11-07T13:32:35Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives: The objective of this study is to investigate possible damages to kidney tissues of pregnant rats and their fetuses exposed to acrylamide during pregnancy and possible protective effects of vitamin E against these damages. Material and methods: Rats were randomly assigned to five groups of control, corn oil, vitamin E, acrylamide, vitamin E + acrylamide, six pregnant rats in each. Mother and fetal kidney tissues were examined for malondialdehyde (MDA), reductase glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS), urea, creatine, trace elements such as Zn and Cu in the serum and histopathological analyses were conducted. Results: It was determined that acrylamide, administered during pregnancy, statistically significantly increased MDA and TOS levels, maternal serum urea, creatinine, and Zn levels, while it decreased GSH, TAS, SOD, and CAT levels (p <= .05) when compared with all other groups in the kidney tissues of pregnant rats and their fetuses and caused tubular degeneration, hemorrhage, narrowing, and closure in Bowman's space, and, in the E vitamin group, it statistically significantly increased GSH, TAS, SOD, CAT, urea, creatinine, and Zn levels when compared with other groups and lowered TOS and MDA levels to those of the control group (p < .05) and there were no differences between the groups histologically. Conclusion: It was observed that acrylamide administered during pregnancy caused oxidative stress in kidney tissues of mother rats and their fetuses, resulting in tissue damage, and vitamin E application, which is considered to be a powerful antioxidant, inhibited oxidative stress.
dc.identifier.doi10.1080/14767058.2018.1471675
dc.identifier.endpage3756
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue22
dc.identifier.pmid29764249
dc.identifier.scopus2-s2.0-85047161377
dc.identifier.scopusqualityQ2
dc.identifier.startpage3747
dc.identifier.urihttps://doi.org/10.1080/14767058.2018.1471675
dc.identifier.urihttps://hdl.handle.net/11480/15502
dc.identifier.volume32
dc.identifier.wosWOS:000478603200008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAcrylamide
dc.subjectfetus
dc.subjectkidneys
dc.subjectmother
dc.subjectoxidative stress
dc.subjectpregnancy
dc.subjectvitamin E
dc.titleThe effects of acrylamide and vitamin E on kidneys in pregnancy: an experimental study
dc.typeArticle

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