A detailed understanding of the COL10A1 and SOX9 genes interaction based on potentially damaging mutations in gastric cancer using computational techniques

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dc.authoridAl-Khafaji, Khattab/0000-0002-2165-9256
dc.authoridTASKIN-TOK, Tugba/0000-0002-0064-8400
dc.contributor.authorAktas, Sedef Hande
dc.contributor.authorTaskin-Tok, Tugba
dc.contributor.authorAl-Khafaji, Khattab
dc.contributor.authorAkin-Bali, Dilara Fatma
dc.date.accessioned2024-11-07T13:32:35Z
dc.date.available2024-11-07T13:32:35Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractGastric cancer (GC) has limited effective treatment options and is followed up with biomarkers that have insufficient sensitivity and specificity. Recent studies on Collagen Type X Alpha 1 Chain (COL10A1) show that the COL10A1 gene may be a diagnostic and/or prognostic biomarker for different cancer types. Moreover, its relationship with the Sex determining Region Y (SRY)-related HighMobility Group (HMG) box (SOX9) gene which is also a transcription factor, was discovered recently, and co-expression of these two genes are associated with the development of GC. However, to the best of our knowledge, there is no study in the literature on how potential damaging mutations in the SOX9 and COL10A1 genes can affect their interactions. The aim of this study is to investigate the interactions of wild-type and potentially damaging mutated structures of COL10A1 and SOX9 genes. Thus, outputs for drug development and therapeutic strategies for GC can be obtained. For this purpose, structure validation and energy minimization analyses as well as docking and binding affinity calculations were performed. As a result, it was found that all investigated mutations (P563S, I588L, T624A, H165R and N110T) increased the binding affinity between the COL10A1-SOX9 complex, especially the N110T and H165R mutants in SOX9. As a conclusion, the N110T and H165R mutants in SOX9 may contribute to tumor progression. Therefore, it is important to consider these mutations for future therapeutic strategies.
dc.identifier.doi10.1080/07391102.2021.1960194
dc.identifier.endpage11544
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue22
dc.identifier.pmid34380365
dc.identifier.scopus2-s2.0-85112290553
dc.identifier.scopusqualityQ2
dc.identifier.startpage11533
dc.identifier.urihttps://doi.org/10.1080/07391102.2021.1960194
dc.identifier.urihttps://hdl.handle.net/11480/15498
dc.identifier.volume40
dc.identifier.wosWOS:000684442400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectGastric cancer
dc.subjectmolecular dynamics simulation
dc.subjectCOL10A1
dc.subjectSOX9
dc.subjectmutation
dc.titleA detailed understanding of the COL10A1 and SOX9 genes interaction based on potentially damaging mutations in gastric cancer using computational techniques
dc.typeArticle

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