HIGH THYROPEROXIDASE ANTIBODY TITERS MAY PREDICT RESPONSE TO ANTITHYROID DRUG TREATMENT IN GRAVES DISEASE: A PRELIMINARY STUDY

Basit Öğe Kaydı
dc.authoridOnder, Cagatay Emir/0000-0002-0293-2309
dc.contributor.authorGokbulut, P.
dc.contributor.authorKoc, G.
dc.contributor.authorKuskonmaz, S. M.
dc.contributor.authorOnder, C. E.
dc.contributor.authorOmma, T.
dc.contributor.authorFirat, S.
dc.contributor.authorCulha, C.
dc.date.accessioned2024-11-07T13:25:24Z
dc.date.available2024-11-07T13:25:24Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground and aim. Antithyroid drugs are first treatment for Graves hyperthyroidism worldwide. Although remission can be achieved in approximately 40-50% of patients in 12-18 months with antithyroid drugs, this period can be extended up to 24 months. We aimed to evaluate the effect of individual clinical/biochemical variables and GREAT score in predicting response to antithyroid drug in Graves disease.Material and methods. This is a retrospective single-center study including 99 patients with the first episode of Graves disease treated for at least 18 months. The patients were classified into two groups as those who responded to antithyroid medication at 18-24 months (group 1) and those who did not respond at 24 months and continued with low-dose antithyroid medication (group 2).Results. Medical treatment response was obtained in 38 (38.3%) of the patients at 18 months, and in 19 (19.1%) patients at 24 months. Long-term medical treatment (>24 months) was given to the remaining 43 patients due to the lack of response to medical treatment. Thyroid volume and free T4 levels were higher in those followed up with long-term antithyroid drugs, and orbitopathy was more common in this group. Median anti TPO value was significantly higher in group 1 when compared to group 2 (593 U/l and 191.6 U/l respectively). More patients were classified as GREAT class 3 in group 2 when compared to group 1 (46.5% and 12,5% respectively). We analyzed the Thyroperoxidase Antibody(anti TPO) titers, which we divided into three levels, according to groups 1 and 2. Post-hoc Chi-Square analysis revealed that falling into the highest anti TPO category was significantly associated with response to medical therapy in 24 months (p <0.05).Conclusion. According to our study, GREAT score and anti TPO Ab titers at presentation may help predict response to ATD in Graves disease.
dc.identifier.doi10.4183/aeb.2023.195
dc.identifier.endpage200
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue2
dc.identifier.pmid37908881
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.4183/aeb.2023.195
dc.identifier.urihttps://hdl.handle.net/11480/14664
dc.identifier.volume19
dc.identifier.wosWOS:001137531100006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofActa Endocrinologica-Bucharest
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectThyroperoxidase antibody
dc.subjectGraves
dc.subjectantithyroid
dc.titleHIGH THYROPEROXIDASE ANTIBODY TITERS MAY PREDICT RESPONSE TO ANTITHYROID DRUG TREATMENT IN GRAVES DISEASE: A PRELIMINARY STUDY
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu