Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats

Basit Öğe Kaydı
dc.authorid0000-0001-5755-3560
dc.contributor.authorSelamoglu, Zeliha S.
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorCiftci, Osman
dc.contributor.authorGulhan, Mehmet F.
dc.contributor.authorSavci, Ahmet
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2015
dc.departmentNiğde ÖHÜ
dc.description.abstractBackground. The blocking of nitric oxide synthase (NOS) activity may cause vasoconstriction with formation of reactive oxygen species. Propolis is a natural product collected from plants by honeybees. Propolis has biological and pharmacological properties. Objectives. This study was designed to investigate the effects of propolis on catalase (CAT) activity, nitric oxide (NO) and malondialdehyde (MDA) levels in the liver tissues of NOS inhibited rats by N omega-Nitro-L-arginine methyl ester (L-NAME). Material and Methods. Rats were given a NOS inhibitor (L-NAME, 40 mg/kg, intraperitoneally) for 15 days to provoke hypertension and propolis (200 mg/kg, by gavage) the last 5 of the 15 days. Results. Nitric oxide levels in the liver tissue of the rats given L-NAME significantly decreased (p < 0.01). That parameter did not significantly alter in the liver of rats treated with propolis compared to the control group. CAT activity and MDA levels in the liver of the rats administrated L-NAME significantly increased compared to the control group (p < 0.01). These parameters significantly decreased in the liver of the rats given L-NAME + propolis compared to the L-NAME group (p < 0.01). Conclusions. The present data shows that L-NAME in the liver may enhance oxidative stress via inhibited nitric oxide synthase. Our results also suggest that this effect is suppressed by the antioxidant properties of propolis in the liver tissue of NOS inhibited rats
dc.description.sponsorshipNigde University Research Fund [BAP 2008/25]
dc.description.sponsorshipThe Nigde University Research Fund (BAP 2008/25) is gratefully acknowledged for supporting this work.
dc.identifier.endpage232
dc.identifier.issn1899-5276
dc.identifier.issue2
dc.identifier.pmid25931353
dc.identifier.scopus2-s2.0-84930441690
dc.identifier.scopusqualityQ1
dc.identifier.startpage227
dc.identifier.urihttps://hdl.handle.net/11480/3966
dc.identifier.volume24
dc.identifier.wosWOS:000355532300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherWROCLAW MEDICAL UNIV
dc.relation.ispartofADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectL-NAME
dc.subjectliver
dc.subjectoxidative stress
dc.subjectpropolis
dc.subjectrat
dc.titleAntioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu