A retrospective comparative fractal and radiomorphometric analysis of the effect of 3 generations of anti-epileptic drugs on the mandible

Basit Öğe Kaydı
dc.authoridTemur, Katibe Tugce/0000-0001-9947-5679
dc.authoridMagat, Guldane/0000-0003-4418-174X
dc.contributor.authorTemur, Katibe Tugce
dc.contributor.authorMagat, Guldane
dc.contributor.authorOzcan, Sevgi
dc.date.accessioned2024-11-07T13:31:54Z
dc.date.available2024-11-07T13:31:54Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective. The present study investigated the possible impacts of anti-epileptic drugs (AEDs) on trabecular and cortical bone in the mandible.Study Design. Fractal dimension (FD) and the radiomorphometric parameters of mandibular cortical width (MCW), panoramic mandibular index (PMI), and mandibular cortical index (MCI) were assessed on 497 dental panoramic radiographs (DPRs) of patients in the case group and controls. AEDs were compared according to 3 generations, duration of use, and patient age and sex.Results. FD of the angle and body of the mandible and MCW were significantly lower in the case group than in the control group (P < .001). FD values in the ramus and angle were lower in first-generation and third-generation AEDs than in second-generation drugs (P < .011). FD in the mandibular body was lower in first-generation and second-generation AED users than in third-genera-tion drugs (P = .017). Drug use for at least 1 year resulted in significantly lower values for all FDs and MCW values and more class 3 MCI assessments than short-duration use, but PMI was higher with more than 1 year of AED use (P < .020). Age and sex had no significant effects.Conclusions. AEDs caused significant changes in bone compared with controls in some FD values, MCW, and MCI. The effect of drug generation is pronounced in trabecular bone. Anti-epileptic drug use for more than 1 year had a greater effect than short-term use. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;136:255-262)
dc.identifier.doi10.1016/j.oooo.2023.04.014
dc.identifier.endpage262
dc.identifier.issn2212-4403
dc.identifier.issn2212-4411
dc.identifier.issue2
dc.identifier.pmid37271608
dc.identifier.startpage255
dc.identifier.urihttps://doi.org/10.1016/j.oooo.2023.04.014
dc.identifier.urihttps://hdl.handle.net/11480/15111
dc.identifier.volume136
dc.identifier.wosWOS:001055043900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectBone-Mineral Density
dc.subjectPanoramic Radiographs
dc.subjectValproate
dc.subjectDimension
dc.subjectEpilepsy
dc.subjectMorphology
dc.subjectCortex
dc.titleA retrospective comparative fractal and radiomorphometric analysis of the effect of 3 generations of anti-epileptic drugs on the mandible
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu