Jaceosidin: A Natural Flavone with Versatile Pharmacological and Biological Activities

Basit Öğe Kaydı
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridRasul, Azhar/0000-0001-9669-7364
dc.authoridHussain, Dr Syed Makhdoom/0000-0001-5087-3887
dc.authoridShah, Muhammad Ajmal/0000-0003-3471-184X
dc.authoridRiaz, Ammara/0000-0001-5025-9182
dc.authoridHUSSAIN, Ghulam/0000-0001-9090-7789
dc.contributor.authorNageen, Bushra
dc.contributor.authorRasul, Azhar
dc.contributor.authorHussain, Ghulam
dc.contributor.authorShah, Muhammad A.
dc.contributor.authorAnwar, Haseeb
dc.contributor.authorHussain, Syed M.
dc.contributor.authorUddin, Md Sahab
dc.date.accessioned2024-11-07T13:34:12Z
dc.date.available2024-11-07T13:34:12Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNature always remains an inexhaustible source of treasures for mankind. It remains a mystery for every challenge until the completion of the challenge. While we talk about the complicated health issues, nature offers us a great variety of chemical scaffolds and their various moieties packed in the form of natural products e.g., plants, microorganisms (fungi, algae, protozoa), and terrestrial vertebrates and invertebrates. This review article is an update about jaceosidin, a bioactive flavone, from genus Artemisia. This potentially active compound exhibits a variety of pharmacological activities including anti-inflammatory, anti-oxidant, anti-bacterial, anti-allergic and anti-cancer activities. The bioactivities and the therapeutic action of jaceosidin, especially the modulation of different cell signaling pathways (ERK1/2, NF-kappa B, PI3K/Akt and ATM-Chk1/2) which become deregulated in various pathological disorders, have been focused here. The reported data suggest that the bioavailability of this anti-cancer compound should be enhanced by utilizing various chemical, biological and computational techniques. Moreover, it is recommended that researchers and scientists should work on exploring the mode of action of this particular flavone to precede it further as a potent anti-cancer compound.
dc.description.sponsorshipNagai Foundation Tokyo, Japan [NFT-R4-2017, NFT-R-2018]; TWAS-COMSTECH [_17-180 RG/PHA/AS_C]; NRPU [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]; ISESCO [3620]
dc.description.sponsorshipThis study was funded by the research grant from The Nagai Foundation Tokyo, Japan (NFT-R4-2017; NFT-R-2018), TWAS-COMSTECH Research Grant (No._17-180 RG/PHA/AS_C), NRPU Research Grants (8381/Punjab/NRPU/R & D/HEC/2017; 8382/Punjab/NRPU/R&D/HEC/2017) and ISESCO Research Grant (No. 3620).
dc.identifier.doi10.2174/1381612826666200429095101
dc.identifier.endpage466
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue4
dc.identifier.pmid32348212
dc.identifier.scopus2-s2.0-85101869518
dc.identifier.scopusqualityQ2
dc.identifier.startpage456
dc.identifier.urihttps://doi.org/10.2174/1381612826666200429095101
dc.identifier.urihttps://hdl.handle.net/11480/15853
dc.identifier.volume27
dc.identifier.wosWOS:000627119000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Design
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectJaceosidin
dc.subjectnatural products
dc.subjectantioxidant
dc.subjectanti-inflammatory
dc.subjectanti-cancer
dc.subjectanti-mutagenic
dc.titleJaceosidin: A Natural Flavone with Versatile Pharmacological and Biological Activities
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu