4-h mean lactate clearance as a good predictor of adverse outcome in acute cardiogenic pulmonary edema: a pilot study

Basit Öğe Kaydı
dc.authoridUNALAN, ADNAN/0000-0002-9187-9713
dc.authoridVURAL, Abdussamed/0000-0003-4506-916X
dc.authoridKARAPEHLIVAN, MAHMUT/0000-0003-0408-534X
dc.contributor.authorVural, Abdussamed
dc.contributor.authorKarapehlivan, Mahmut
dc.contributor.authorDolanbay, Turgut
dc.contributor.authorCumaoglu, Mustafa Oguz
dc.contributor.authorHatip, Ahmet Yunus
dc.contributor.authorCetinkaya, Yakup
dc.contributor.authorUnalan, Adnan
dc.date.accessioned2024-11-07T13:32:34Z
dc.date.available2024-11-07T13:32:34Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives This pilot study aimed to evaluate the efficacy of the 4-h mean lactate clearance (LACclr) level as a predictive factor for in-hospital outcomes, 30-day mortality, and treatment success in patients with acute cardiogenic pulmonary edema (ACPE), a significant clinical form of acute heart failure (AHF).Methods A total of 44 patients diagnosed with acute pulmonary edema were included in the study. The patients were divided into two groups based on lactate levels and negative outcomes, and lactate and LACclr levels and negative outcomes were analyzed using statistical tests such as Fisher's exact test, Student's t-test, Mann-Whitney U test, and Receiver operating characteristic (ROC) analysis.Results The results indicated a statistically significant difference in the total hospitalization length of stay according to whether the patients had a negative outcome (intubation and in-hospital mortality) (p=0.033). Additionally, the area under the curve (AUC) value for 4-h mean LACclr was 0.795 in all patients, which was statistically significant in predicting 30-day mortality (p=0.033). The optimal cut-off value for the 4-h mean LACclr in predicting 30-day mortality was found to be 5.57 %, with 80 % sensitivity and 66.7 % specificity. The threshold to rule out 30-day mortality for all patients was 18.85 with 100 % sensitivity and 30.2 % specificity (AUC, 0.795 95 % CI [0.546-1.000], p=0.033).Conclusions These findings suggest that the 4-h LACclr level, calculated within 4 h of emergency department (ED) presentation, can be used as a predictive indicator for needing intubation, in-hospital mortality, and 30-day mortality and to identify patients at higher risk for adverse outcomes.
dc.identifier.doi10.1515/tjb-2023-0255
dc.identifier.endpage409
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.startpage401
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0255
dc.identifier.urihttps://hdl.handle.net/11480/15489
dc.identifier.volume49
dc.identifier.wosWOS:001234131000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectacute heart failure
dc.subjectacute pulmonary edema
dc.subjectcardiogenic
dc.subjectlactate
dc.subjectlactate clearance
dc.subjectprognosis
dc.title4-h mean lactate clearance as a good predictor of adverse outcome in acute cardiogenic pulmonary edema: a pilot study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu