Synthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agents

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dc.authorid0000-0003-2904-160X
dc.contributor.authorBayrakci, Mevlut
dc.contributor.authorErtul, Seref
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2012
dc.departmentNiğde ÖHÜ
dc.description.abstractThis study presents the selective chloromethylation of calix[4](aza)crown ethers 2a-c, using chloromethyl n-octyl ether and SnCl4 in chloroform at room temperature in good yield for the first time. Chloromethylated products 2a-c are used as key intermediates to synthesize new water-soluble p-phosphonato calix[4](aza)crown ethers 5a-c. Liquid-liquid phase extraction and phase solubility studies with poor water soluble drug molecules such as nifedipine, niclosamide and furosemide are performed to evaluate their binding properties. Among the studied drugs, furosemide was the most effectively dissolved drug by p-phosphonato calix[4](aza)crown ethers 5a-c in water.
dc.description.sponsorshipS.U. Research Foundation [BAP: 10101016]
dc.description.sponsorshipThis study is part of the PhD Thesis of Mevlut Bayrakci and the authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.
dc.identifier.doi10.1007/s10847-012-0115-y
dc.identifier.endpage303
dc.identifier.issn1388-3127
dc.identifier.issn1573-1111
dc.identifier.issue45383
dc.identifier.scopus2-s2.0-84864443175
dc.identifier.scopusqualityQ3
dc.identifier.startpage293
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-012-0115-y
dc.identifier.urihttps://hdl.handle.net/11480/4515
dc.identifier.volume74
dc.identifier.wosWOS:000306946700029
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCalixarene
dc.subjectChloromethylation
dc.subjectNiclosamide
dc.subjectFurosemide
dc.subjectNifedipine
dc.titleSynthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agents
dc.typeArticle

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