Association of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population

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dc.authoridTezcan Ulger, Seda/0000-0002-0823-3680
dc.authoridAYDIN, FATMA ESIN/0000-0001-6677-0233
dc.contributor.authorKirik, Fatma Esin
dc.contributor.authorUlger, Mahmut
dc.contributor.authorUlger, Seda Tezcan
dc.contributor.authorAslan, Gonul
dc.date.accessioned2024-11-07T13:32:02Z
dc.date.available2024-11-07T13:32:02Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAims The objective of this study was to determine the association of TNF-alpha -308 G/A, IFN-gamma +874 T/A, IL-12B + 1188 A/C, IL-10 -1082 G/A and IL-4 -590 C/T polymorphisms with susceptibility to CL. Methods and Results A total of 55 CL patients and 110 controls from Sanliurfa province of Turkey were included to this study. Polymorphisms were genotyped by 'polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)' and 'amplification refractory mutation system-PCR (ARMS-PCR)' methods. A statistically significant difference was noted in the allele (P < .001,P = .002) and genotype (P < .001,P = .001,) frequencies of TNF-alpha -308 G/A and IL-4 -590 C/T, respectively. TNF-alpha 308 GG versus GA genotype (OR = 19.556 [95% CI 8.310-46.019]P < .001), GG versus GA + AA genotype (OR = 20.444 [95% CI 8.707-48.004]P < .001) and G versus A allele (OR = 6.968 [95% CI 3.903-12.440]P < .001) revealed significant association with CL. IL-4 -590 CC versus TT + CT genotype (OR = 2.049 [95% CI 1.025-4.096],P = .041) and C versus T allele (OR = 2.441 [95% CI 1.355-4.396],P = .002) revealed significant association with CL. Conclusion Our study indicates that TNF-alpha 308 G/A and IL-4-590 C/T polymorphisms are significantly associated with susceptibility to CL. Individuals carrying A allele at TNF-alpha promoter -308 position and T allele at IL-4 promoter -590 position are at a higher risk for CL.
dc.description.sponsorshipScientific Research Projects Department of Mersin University [BAP-SBE TMAD (FEA) 2013-4(DR)]
dc.description.sponsorshipWe would like to thank to the Scientific Research Projects Department of Mersin University for funding our research [Project number BAP-SBE TMAD (FEA) 2013-4(DR)]. The study protocol was approved by the Ethical Committee of the Mersin University (Ethical Committee Approval No: 2009/55-04, Date: 17 April 2009). This study was presented as an oral presentation at XXXVII. Turkish Microbiology Congress, International Symposium on Parasitic Zoonoses, 16-20 November 2016, Antalya, Turkey.
dc.identifier.doi10.1111/pim.12775
dc.identifier.issn0141-9838
dc.identifier.issn1365-3024
dc.identifier.issue11
dc.identifier.pmid32656817
dc.identifier.scopus2-s2.0-85088801621
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/pim.12775
dc.identifier.urihttps://hdl.handle.net/11480/15177
dc.identifier.volume42
dc.identifier.wosWOS:000553404600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofParasite Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAntiinflammatory Cytokines
dc.subjectImmune-Responses
dc.subjectTnf-Alpha
dc.subjectInfection
dc.subjectVariants
dc.subjectPromoter
dc.subjectTh1/Th2
dc.subjectTurkey
dc.subjectIl4
dc.titleAssociation of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population
dc.typeArticle

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