Relation between mean platelet volume and subclinical atherosclerosis in patients with metabolic syndrome [Metabolik sendromlu hastalarda ortalama trombosit hacminin subklinik ateroskleroz ile ilişkisi]

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Turkish Anaesthesiology and Intensive Care Society

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objectives: Metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. There is evidence of platelet activation in MetS. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. Therefore, we investigated the possible association between subclinical atherosclerosis, as evaluated by carotid intima-media thickness (CIMT) measurement and MPV, in MetS patients. Study design: Seventy-four patients with MetS were enrolled in the study. Patients were divided into two groups according to CIMT measurement: 35 patients with CIMT ?1.0 mm were in Group 1 and 39 patients with CIMT <1.0 mm were in Group 2. MPV was measured using an automated blood cell counter. Results: The MPV level was significantly higher in patients with CIMT ?1.0 mm than in patients with CIMT <1.0 mm (8.2±0.7 vs. 7.8±0.6 fl; p=0.01). In our study, we observed that platelet count was lower in KIMK ?1.0 mm group and this finding was also found to be statistically significant. Conclusion: The risk of atherosclerosis could be shown by following the MPV values in MetS patients. Therefore, our results suggest that MPV is an important marker for early detection of atherosclerotic risk in patients with MetS. © 2014 Türk Kardiyoloji Dernegi.

Açıklama

Anahtar Kelimeler

Atherosclerosis, Blood platelets/pathology, Metabolic syndrome X, Platelet activation, Platelet count

Kaynak

Turk Kardiyoloji Dernegi Arsivi

WoS Q Değeri

Scopus Q Değeri

Cilt

42

Sayı

1

Künye