Beta-lactam antibiotic-induced thrombocytopenia: MYH9 & TUBB1 genes

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dc.contributor.authorOzkan, Didem
dc.contributor.authorAkisin, Yasemin Ardicoglu
dc.contributor.authorBali, Dilara Fatma Akin
dc.contributor.authorAkar, Nejat
dc.date.accessioned2024-11-07T13:34:04Z
dc.date.available2024-11-07T13:34:04Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: Macrothrombocytopenia is a congenital autosomal-dominant blood disorder characterized by increased platelet size and a decreased number of circulating platelets. In this study, it was aimed to show the MYH9 and TUBB1 gene changes, which are the genes associated with the disease, in a patient with thrombocytopenia receiving beta-lactam antibiotic therapy. Material and Methods: In this study, coagulation parameters and platelet aggregation tests were performed after ingestion of a beta-lactam antibiotic in an 8-year-old boy with thrombocytopenia, the MYH9 and TUBB1 genes were scanned by PCR and DNA sequencing, and the results were subsequently analyzed using bioinformatics tools. Results: We found previously described TUBB1 polymorphisms, p.R307H , p.Q43P, p.T178T and the novel mutation p.K64A in the MYH9 gene in a boy and his mother. Changes in genes important for thrombocytopenia in a boy after taking beta-lactam antibiotics prompted us to study the same genes in the mother, since her mother had macrothrombocytopenia, and we found a new mutation in her mother Discussion: Determination of gene changes after beta-lactam antibiotic use in bleeding patients is important in terms of helping the clinic in the treatment.
dc.identifier.doi10.4328/ACAM.21174
dc.identifier.endpage977
dc.identifier.issn2667-663X
dc.identifier.issue9
dc.identifier.startpage973
dc.identifier.urihttps://doi.org/10.4328/ACAM.21174
dc.identifier.urihttps://hdl.handle.net/11480/15767
dc.identifier.volume13
dc.identifier.wosWOS:000863271700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectPlatelets
dc.subjectMacrothrombocytopenia
dc.subjectMYH9
dc.titleBeta-lactam antibiotic-induced thrombocytopenia: MYH9 & TUBB1 genes
dc.typeArticle

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