Living with female rats exposed to restraint stress during pregnancy caused depressive-like behavior in male rats and stress-induced apoptosis

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dc.authoridkocahan, sayad/0000-0002-3161-1280
dc.authoridakillioglu, kubra/0000-0003-4896-8822
dc.authoridsahin, leyla/0000-0003-2840-1116
dc.contributor.authorKocahan, Sayad
dc.contributor.authorAkillioglu, Kubra
dc.contributor.authorSencar, Leman
dc.contributor.authorSahin, Leyla
dc.contributor.authorCevik, Ozge Selin
dc.contributor.authorTaskin, Eylem
dc.contributor.authorGuven, Celal
dc.date.accessioned2024-11-07T13:35:18Z
dc.date.available2024-11-07T13:35:18Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective Maternal mood disorders such as postpartum depression (PPD) can negatively affect the lives not only of mothers but also of partners. The purpose of this study investigates emotional behavior and hippocampal apoptosis alterations of the male live with a postpartum depressed female. Methods Pregnant rats in the stress group were exposed to restraint stress (RS). The male rats who shared the same cages were not exposed to RS. To explain the consequences of depressive-like behavior and anxiety, animals were exposed to the forced swim test (FST), open-field test (OFT), and elevated plus maze (EPM). The apoptotic cell number was detected by terminal deoxynucleotidyl transferase (Tdt)-mediated dUTP biotin nick-end labeling (TUNEL) staining. Results According to FST, PPD caused more immobility, reduced swimming, and climbing compared to control groups in the stressed female and male (p < 0.05). For the crossing number of squares in the center area, the main effect of the group was significant (p < 0.05). Stressed groups have a higher crossing number of squares in the center area compared to control groups. In the OFT, there was a significant increase in the time spent in the center area in the stress female and male group compared to the control female and male group (p < 0.05). For the EPM, time spent in the close arms was increased in the control male and stress male compared to the stress female group (p < 0.05). Female and male rats with PPD demonstrated apoptosis in neuron and glial cells in the hippocampus. Conclusions The present study demonstrates that RS results in PPD in females. Furthermore, it implicates RS as a potential risk factor for the development of postpartum mood disorder in males. Most of the studies on paternal PPD have been done by using self-report questionnaires. Studies on physiological and hormonal changes during the postpartum period among fathers would provide information on biological factors of depression.
dc.description.sponsorshipAdiyaman University Research Foundation [TIPFBAP/2013-0002]
dc.description.sponsorshipAdiyaman University Research Foundation, Grant/Award Number: TIPFBAP/2013-0002
dc.identifier.doi10.1002/jdn.10142
dc.identifier.endpage654
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.issue7
dc.identifier.pmid34228828
dc.identifier.scopus2-s2.0-85110214807
dc.identifier.scopusqualityQ3
dc.identifier.startpage643
dc.identifier.urihttps://doi.org/10.1002/jdn.10142
dc.identifier.urihttps://hdl.handle.net/11480/16441
dc.identifier.volume81
dc.identifier.wosWOS:000674033400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectanxiety
dc.subjectapoptosis
dc.subjecthippocampus
dc.subjectpostpartum depression
dc.subjectrestraint stress
dc.titleLiving with female rats exposed to restraint stress during pregnancy caused depressive-like behavior in male rats and stress-induced apoptosis
dc.typeArticle

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