Nationwide study of Escherichia coli producing extended-spectrum ß-lactamases TEM, SHV and CTX-M in Turkey

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dc.contributor.authorCopur Cicek A.
dc.contributor.authorSaral A.
dc.contributor.authorOzad Duzgun A.
dc.contributor.authorYasar E.
dc.contributor.authorCizmeci Z.
dc.contributor.authorOzlem Balci P.
dc.contributor.authorEsra Budak E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractFour hundred and forty extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), blood (6.59%), cerebrospinal fluid (1.13%), pleural fluid (2.95%), wound (4.31%) and sputum (4.54%). ESBL-coding genes (CTX-M1, CTX-M2, TEM, SHV) were detected by PCR. According to the PCR and sequencing results, CTX-M1 was the most prevalent ß-lactamase 83.18% (366/440), followed by TEM 44.09% (194/440), CTX-M2 31.81% (140/440) and SHV 1.81% (8/440). Sequencing results showed that TEM and SHV types were TEM-1b and SHV-11, respectively. Rate of the strains harboring only CTX-M1, CTX-M2, TEM-1b and SHV-11 were 30.90%, 3.63%, 2.27% and 0.23%, respectively. Rate of the strains harboring the combinations of CTX-M1-CTX-M2, CTX-M1-CTX-M2-TEM-1b, CTX-M2-TEM-1b, CTX-M1-TEM-1b, CTX-M1-CTX-M2-TEM-1b-SHV-11, CTX-M1-TEM-1b-SHV-11, CTX-M1-SHV-11, CTX-M1-CTX-M2-SHV-11, CTX-M2-SHV-11, CTX-M2-TEM-1b-SHV-11, TEM-1b-SHV-11 were 12.95%, 11.59%, 2.95%, 26.13%, 0.45%, 0.68%, 0.22%, 0.22%, 0%, 0% and 0%, respectively. This is a nationwide study of ESBL-producing E. coli in Turkey. These results shows that CTX-M1 group is the most common type of class A ß-lactamases among ESBL-producing E. coli strains in Turkey. © 2013 Japan Antibiotics Research Association.
dc.description.sponsorshipRecep Tayyip Erdogan Üniversitesi Fundamental Research Fund of Shandong University
dc.description.sponsorshipThis work was supported by Recep Tayyip Erdogan University Research Fund Grants BAP-2012.106.01.11 and BAP-2011.102.03.3.
dc.identifier.doi10.1038/ja.2013.72
dc.identifier.endpage650
dc.identifier.issn0021-8820
dc.identifier.issue11
dc.identifier.pmid23838745
dc.identifier.startpage647
dc.identifier.urihttps://dx.doi.org/10.1038/ja.2013.72
dc.identifier.urihttps://hdl.handle.net/11480/801
dc.identifier.volume66
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofJournal of Antibiotics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectß-lactamase
dc.subjectCTX-M1
dc.subjectCTX-M2
dc.subjectSHV-11
dc.subjectTEM-1b
dc.titleNationwide study of Escherichia coli producing extended-spectrum ß-lactamases TEM, SHV and CTX-M in Turkey
dc.typeArticle

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