The Effects of Sex Hormones on Postoperative Pain in Patients with Laparoscopic Cholecystectomy

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dc.contributor.authorKoras Sozen, Kezban
dc.contributor.authorBolat, Haci
dc.contributor.authorGunturk, Inayet
dc.date.accessioned2024-11-07T13:24:46Z
dc.date.available2024-11-07T13:24:46Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: There are many factors that affect postoperative pain. This study determines the effect of preoperative sex hormone levels on postoperative pain levels in patients undergoing laparoscopic cholecystectomy. Patients and Methods: This study included a total of 89 patients who met the study inclusion criteria. The patients were divided into 3 groups based on their sex and pre and postmenopausal periods: male patients (n = 28), postmenopausal female patients (n = 31), and female patients with normal cycles (n = 30). Normal-cycle women were also regrouped based on their follicular and luteal phases. Data were collected using a descriptive characteristics form, a patient follow-up form, and the Visual Analog Scale. Results: Venous blood samples taken from the patients before surgery were used to measure their levels of estradiol (EST), testosterone (TES), and progesterone levels. Male patients had lower pain levels than female patients. The male patients' Visual Analog Scale scores were inversely related and correlated strongly with their TES levels (P < 0.05). However, subgroup analyses suggested that their EST level played a primary role in males and that the EST/TES ratio was determinant in the late postoperative period. In female patients, the EST/progesterone ratio was the most determining factor for the level of pain felt in the postmenopausal period, whereas there was no change in the premenopausal period at different stages of the menstrual cycle. Conclusions: Sex hormones were found to be effective in predicting postoperative pain severity.
dc.description.sponsorshipResearch Fund of Nigde Omer Halisdemir University Scientific Research Projects [SAT 2020/5-HIDEP]
dc.description.sponsorshipThis study was supported by the Research Fund of Nigde Omer Halisdemir University Scientific Research Projects (Grant No: SAT 2020/5-HIDEP).
dc.identifier.doi10.1097/SLE.0000000000001259
dc.identifier.endpage19
dc.identifier.issn1530-4515
dc.identifier.issn1534-4908
dc.identifier.issue1
dc.identifier.pmid38241658
dc.identifier.scopus2-s2.0-85184153010
dc.identifier.scopusqualityQ2
dc.identifier.startpage14
dc.identifier.urihttps://doi.org/10.1097/SLE.0000000000001259
dc.identifier.urihttps://hdl.handle.net/11480/14301
dc.identifier.volume34
dc.identifier.wosWOS:001156433100008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofSurgical Laparoscopy Endoscopy & Percutaneous Techniques
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectsex hormones
dc.subjectlaparoscopic cholecystectomy
dc.subjectpostoperative pain
dc.subjectmenstrual cycle
dc.titleThe Effects of Sex Hormones on Postoperative Pain in Patients with Laparoscopic Cholecystectomy
dc.typeArticle

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