SLPred: a multi-view subcellular localization prediction tool for multi-location human proteins

Küçük Resim Yok

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Oxford Univ Press

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Accurate prediction of the subcellular locations (SLs) of proteins is a critical topic in protein science. In this study, we present SLPred, an ensemble-based multi-view and multi-label protein subcellular localization prediction tool. For a query protein sequence, SLPred provides predictions for nine main SLs using independent machine-learning models trained for each location. We used UniProtKB/Swiss-Prot human protein entries and their curated SL annotations as our source data. We connected all disjoint terms in the UniProt SL hierarchy based on the corresponding term relationships in the cellular component category of Gene Ontology and constructed a training dataset that is both reliable and large scale using the re-organized hierarchy. We tested SLPred on multiple benchmarking datasets including our-in house sets and compared its performance against six state-of-the-art methods. Results indicated that SLPred outperforms other tools in the majority of cases.

Açıklama

Anahtar Kelimeler

Ontology, Sequence

Kaynak

Bioinformatics

WoS Q Değeri

Q1

Scopus Q Değeri

Q1

Cilt

38

Sayı

17

Künye