Maternal N-carbamylglutamate and L-arginine supplementations improve foetal jejunal oxidation resistance, integrity and immune function in malnutrition sheep during pregnancy

Basit Öğe Kaydı
dc.contributor.authorZhang, Hao
dc.contributor.authorZhang, Bei
dc.contributor.authorWu, Huisi
dc.contributor.authorZha, Xia
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorZhao, Jingwen
dc.contributor.authorWang, Hongrong
dc.date.accessioned2024-11-07T13:35:04Z
dc.date.available2024-11-07T13:35:04Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe present work focused on examining the function of rumen-protected L-arginine (RP-Arg) or N-carbamylglutamate (NCG) in jejunal oxidative resistance, integrity and immune function in the ovine foetal model of intrauterine growth restriction (IUGR). Thirty-two twin-bearing Hu ewes at d 35 of gestation were randomised as 4 treatment groups (n = 8 each): Control (CON), received 100% of the recommended National Research Council (NRC) for pregnancy; Restricted (RES), received 50% of the recommended NRC for pregnancy; RES + ARG, RES ewes added with 20 g/d of RP-Arg; or RES + NCG treatment, RES ewes added with 5 g/d of NCG. Foetal jejunal samples were collected on d 110 of pregnancy and were assayed for biomarkers of oxidative damage, integrity and immune function. The villus height was elevated (p < .05) within the jejunum of the foetuses of RES ewes subjected to dietary NCG or Arg supplementation relative to the RES group. RES + NCG or RES + ARG feeding decreased (p < .05) foetal jejunal tumour necrosis factor-alpha (TNF-alpha) and Interleukin (IL)-6 levels and elevated (p < .05) foetal jejunal superoxide dismutase (SOD) activity (p < .05) in relative to RES group. The Arg/NCG supplementation downregulated (p < .05) expression of gene and proteins associated with inflammatory response (TNF-alpha), upregulated (p < .05) genes and proteins associated with antioxidation (catalase and SOD2) and integrity (claudin-1) relative to those within foetal jejunum of RES group. In conclusion, Arg and NCG supplementation of RES ewes alleviates foetal jejunal oxidative stress, improves integrity, and promotes foetal intestinal development in the ovine foetus with IUGR.
dc.description.sponsorshipProject of National Key Research and Development Program of China [2023YFD1301705]; Top Talents Award Plan of Yangzhou University; Cyanine Project of Yangzhou University
dc.description.sponsorshipThe work was funded by the fund for the Project of National Key Research and Development Program of China (2023YFD1301705), the Top Talents Award Plan of Yangzhou University (2020), and the Cyanine Project of Yangzhou University (2020).
dc.identifier.doi10.1080/1828051X.2024.2374870
dc.identifier.endpage1001
dc.identifier.issn1594-4077
dc.identifier.issn1828-051X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85197922514
dc.identifier.scopusqualityQ1
dc.identifier.startpage989
dc.identifier.urihttps://doi.org/10.1080/1828051X.2024.2374870
dc.identifier.urihttps://hdl.handle.net/11480/16319
dc.identifier.volume23
dc.identifier.wosWOS:001263025300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofItalian Journal of Animal Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectIntrauterine growth restriction
dc.subjectintestinal integrity
dc.subjectL-arginine
dc.subjectN-carbamylglutamate
dc.subjectoxidation resistance
dc.titleMaternal N-carbamylglutamate and L-arginine supplementations improve foetal jejunal oxidation resistance, integrity and immune function in malnutrition sheep during pregnancy
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu