Effects of oxidative stress and apoptosis on vascularity and viability of perforator flaps

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dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.authoridTuglu, Mehmet Ibrahim/0000-0002-0569-8415
dc.contributor.authorBali, Ulas
dc.contributor.authorAydemir, Isil
dc.contributor.authorKececi, Yavuz
dc.contributor.authorYoleri, Levent
dc.contributor.authorTuglu, Mehmet Ibrahim
dc.date.accessioned2024-11-07T13:32:23Z
dc.date.available2024-11-07T13:32:23Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractWe investigated lateral thoracic and posterior thigh perforator flaps for viability, vascularization, perfusion and apoptosis in a rat model. Wistar albino rats were divided into six groups: lateral thoracic artery perforator flap (LTPF) sham, 3 x 2 cm(2) LTPF, 3 x 6 cm(2) LTPF, posterior thigh perforator flap (PTPF) sham, 3 x 2 cm(2) PTPF, and 3 x 6 cm(2) PTPF. Flap viability was determined on postoperative days 1 and 7. On day 7, flaps were photographed and their viability was measured using two-dimensional planimeter paper. Tissue samples were harvested for examination by histology and immunohistochemistry. Viability differences were statistically significant. Epithelial thickness, vascularity and number of fibroblasts were reduced in the 3 x 6 cm(2) groups. Neovascularization and apoptosis based on molecular tests were not significantly different among groups. Flap size and location are important factors for closure of surgical or traumatic defects. We suggest that for clinical application, wound complications will occur less frequently with perforators that nourish large areas of flaps.
dc.identifier.doi10.1080/10520295.2020.1831066
dc.identifier.endpage535
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue7
dc.identifier.pmid33107764
dc.identifier.scopus2-s2.0-85094585533
dc.identifier.scopusqualityQ2
dc.identifier.startpage526
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1831066
dc.identifier.urihttps://hdl.handle.net/11480/15380
dc.identifier.volume96
dc.identifier.wosWOS:000584817100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectApoptosis
dc.subjectneovascularization
dc.subjectoxidative stress
dc.subjectperforator flap
dc.subjectrats
dc.titleEffects of oxidative stress and apoptosis on vascularity and viability of perforator flaps
dc.typeArticle

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