Ultrasound-assisted extraction of antioxidant phenolic compounds from Lavandula angustifolia flowers using natural deep eutectic solvents: An experimental design approach

Basit Öğe Kaydı
dc.authoridALASALVAR, Hamza/0000-0003-3000-7310
dc.contributor.authorAlasalvar, Hamza
dc.contributor.authorYildirim, Zeliha
dc.date.accessioned2024-11-07T13:24:46Z
dc.date.available2024-11-07T13:24:46Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, the green extraction of antioxidant phenolic compounds from Lavandula angustifolia was investigated using ultrasound-assisted extraction coupled with natural deep eutectic solvents (NADESs). One variable at a time, fractional factorial design, steepest ascent/descent method, and central composite design were used to optimize the extraction conditions. Eighteen NADESs based on choline chloride, organic acids, and sugars were tested by one variable at a time approach. The NADES composed of choline chloride and glycerol with a molar ratio of 1:2 showed higher extraction performance than other NADESs and benchmark solvents (70 % ethanol and 80 % methanol). After solvent selection, other extraction parameters including ultrasound amplitude (20-100 %), temperature (40-70 degrees C), time (5-30 min), liquid to solid ratio (10-50 mL/g), and water content in NADES (10-50 %) were screened using fractional factorial design. Subsequently, the steepest ascent/descent method was applied to approach the suitable level of the selected parameters. Finally, response surface methodology was used to determine the optimal extraction conditions. The optimum conditions were ultrasound amplitude of 60 %, temperature of 60 degrees C, time of 17.5 min, liquid to solid ratio of 31.7 mL/g, and water content in NADES of 33.5 % with the predicted phenolic content of 50.50 mg gallic acid equivalent/g, flavonoid content of 35.79 mg catechin equivalent/g, antioxidant capacity (AC)(DPPH )of 41.60 mg Trolox equivalent (TE)/g, AC(ABTS) of 77.13 mg TE/g, and AC(CUPRAC) of 163.33 mg TE/g. Phenolics and volatiles were analyzed by HPLC and GC-MS, respectively. The results showed a sustainable, green, and effective extraction of antioxidant phenolic compounds from L. angustifolia.
dc.description.sponsorshipUnit of the Scientific Research Projects of Nigde Omer Halisdemir University [TGT2021/2-LUTEP]
dc.description.sponsorshipThis study was a part of H.A.'s Ph.D. thesis and was supported by the Unit of the Scientific Research Projects of Nigde Omer Halisdemir University (TGT2021/2-LUTEP) .
dc.identifier.doi10.1016/j.scp.2021.100492
dc.identifier.issn2352-5541
dc.identifier.scopus2-s2.0-85111725189
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.scp.2021.100492
dc.identifier.urihttps://hdl.handle.net/11480/14308
dc.identifier.volume22
dc.identifier.wosWOS:000691286300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSustainable Chemistry and Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectLavandula angustifolia
dc.subjectNatural deep eutectic solvent
dc.subjectGreen extraction
dc.subjectAntioxidant capacity
dc.subjectExperimental design
dc.titleUltrasound-assisted extraction of antioxidant phenolic compounds from Lavandula angustifolia flowers using natural deep eutectic solvents: An experimental design approach
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu