The Effects of Diflubenzuron on Acetylcholinesterase (EC 3.1.1.7) Activity and Liver Ultrastructure in Wistar Rats

Basit Öğe Kaydı
dc.authoridYazici Ozcelik, Eda/0000-0001-6657-4777
dc.authoridEskizengin, Hakan/0000-0003-1709-7497
dc.authoridGUL, Nursel/0000-0003-2978-4163
dc.contributor.authorGul, Nursel
dc.contributor.authorYigit, Nuri
dc.contributor.authorYigit, Fulya Saygili
dc.contributor.authorOzcelik, Eda Yazici
dc.contributor.authorEskizengin, Hakan
dc.date.accessioned2024-11-07T13:34:26Z
dc.date.available2024-11-07T13:34:26Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractDiflubenzuron is a commonly used larvicide/biocidal substance. The present study aimed to reveal the effects of diflubenzuron on Acetylcholinesterase (AChE) enzymatic activity and liver histopathology of a mammalian species (rats). The animals fed with various doses of diflubenzuron and the liver tissues of rats were taken on the 10th, 20th, 25th, 45th days and sixth month. AChE activity of liver was measured by spectrophotometer. Tissues were embedded in Araldite 502 (Sigma), took ultrathin sections, and examined under a 100 CX II Transmission Electron Microscope. AChE activity in the chronic dose of diflubenzuron group was like that in the control group. The enzymatic activity in the subacute dose was found to be significantly different from the control group. After subacute dose exposure was terminated, the AChE activity was still lower on the 45th day compared with the control group. Chronic and subacute doses caused adverse effects to liver tissues, such as numerous mitochondria, abnormally structured nuclei in the hepatocytes and many lipid droplets in the sinusoids of the liver ultrastructure. After the subacute dose was terminated, liver damage was still observed on the 20th and 25th days, but the liver tissue was partly regenerated on the 45th day. Cellular damage might recover after 45 days, but AChE activity probably takes more time to reach a normal level.
dc.identifier.doi10.35378/gujs.868668
dc.identifier.endpage78
dc.identifier.issn2147-1762
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85150679862
dc.identifier.scopusqualityQ3
dc.identifier.startpage68
dc.identifier.urihttps://doi.org/10.35378/gujs.868668
dc.identifier.urihttps://hdl.handle.net/11480/15970
dc.identifier.volume36
dc.identifier.wosWOS:000979511700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ
dc.relation.ispartofGazi University Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectDiflubenzuron
dc.subjectRat
dc.subjectLiver ultrastructure
dc.subjectAcetylcholinesterase
dc.subjectenzymatic activity
dc.titleThe Effects of Diflubenzuron on Acetylcholinesterase (EC 3.1.1.7) Activity and Liver Ultrastructure in Wistar Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu