Antioxidative and antiproliferative effects of propolis-reduced silver nanoparticles

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dc.authoridFOTO, Egemen/0000-0002-0305-5467
dc.authoridZILIFDAR FOTO, Fatma/0000-0002-7161-5286
dc.authoridIlk, Sedef/0000-0002-6754-792X
dc.contributor.authorTan, Gamze
dc.contributor.authorIlk, Sedef
dc.contributor.authorFoto, Fatma Z.
dc.contributor.authorFoto, Egemen
dc.contributor.authorSaglam, Necdet
dc.date.accessioned2024-11-07T13:35:07Z
dc.date.available2024-11-07T13:35:07Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, phytochemicals present in Propolis Extract (PE) were employed as reducing and stabilizing reagents to synthesize silver nanoparticles. Three propolis-reduced silver nanoparticles (P-AgNPs1-3) were synthesized using increasing amounts of PE. P-AgNPs were treated with different cancer cells -lung (A549), cervix (HeLa) and colon (WiDr) for 24, 48 and 72 h to evaluate their anti -proliferative activities. A non-cancerous cell type (L929) was also used to test whether suppressive effects of P-AgNPs on cancer cell proliferation were due to a general cytotoxic effect. The characterization results showed that the bioactive contents in propolis successfully induced particle formation. As the amount of PE increased, the particle size decreased; however, the size distribution range expanded. The antioxidant capacity of the particles increased with increased propolis amounts. P-AgNP1 exhibited almost equal inhibitory effects across all cancer cell types; however, P-AgNP2 was more effective on HeLa cells. P-AgNPs3 showed greater inhibitory effects in almost all cancer cells compared to other NPs and pure propolis. Consequently, the biological effects of P-AgNPs were highly dependent on PE amount, NP concentration, and cell type. These results suggest that AgNPs synthesized utilizing propolis phytochemicals might serve as anti -cancer agents, providing greater efficacy against cancer cells.
dc.identifier.doi10.12989/anr.2021.10.2.139
dc.identifier.endpage150
dc.identifier.issn2287-237X
dc.identifier.issn2287-2388
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85105822367
dc.identifier.scopusqualityQ1
dc.identifier.startpage139
dc.identifier.urihttps://doi.org/10.12989/anr.2021.10.2.139
dc.identifier.urihttps://hdl.handle.net/11480/16350
dc.identifier.volume10
dc.identifier.wosWOS:000643257800004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTechno-Press
dc.relation.ispartofAdvances in Nano Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectpropolis
dc.subjectsilver nanoparticles
dc.subjectDPPH
dc.subjectSRB assay
dc.subjectanti -cancer activity
dc.subjectcytotoxicity
dc.titleAntioxidative and antiproliferative effects of propolis-reduced silver nanoparticles
dc.typeArticle

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