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    Age-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography
    (2013) Celebi A.R.C.; Mirza G.E.
    PURPOSE. We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SDOCT) in healthy individuals. METHODS. In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear regression analysis and Spearman's correlation analysis were performed to investigate the level of difference in age-related change in the overall mean, 4 quadrants mean, and 12 clock-hour sectors mean RNFLT. RESULTS. Mean age of the 121 healthy participants was 39 years (range, 20-59 years). Mean 4 quadrant and mean 12 clock-hour sector RNFLT in the 121 randomly selected eyes in 121 healthy participants decreased significantly with age in the overall group (Spearman's correlation analysis, P < 0.05). Overall mean RNFLT decreased by 0.365 lm (95% confidence interval [CI], 0.47-0.26; linear regression analysis, P < 0.001) for every one year increase in age. Overall, the greatest decrease in mean RNFLT was in the lower quadrant (0.575 lm/y; 95% CI, 0.733-0.416), versus the least decrease in the nasal quadrant (0.141 lm/y; 95% CI, 0.272-0.010), and the greatest decrease in mean RNFLT was in the 6 clock-hour sector (0.656 lm/y; 95% CI, 0.939-0.374), versus the least decrease in the 3 clock-hour sector (0.119 lm/y; 95% CI, 0.266-0.029). CONCLUSIONS. Age-related decrease in RNFLT varied according to sector. Age-related change should be accounted for in any assessment of RNFLT. Regional age-related change is accounted for by Cirrus SD-OCT in its normative database.© 2013 The Association for Research in Vision and Ophthalmology, Inc.
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    The efficacy of autologous serum eye drops for severe dry eye syndrome: A randomized double-blind crossover study
    (Springer Verlag, 2014) Celebi A.R.C.; Ulusoy C.; Mirza G.E.
    Background: To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). Methods: This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results: The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P??0.05 [Mann-Whitney U test]). Conclusions: AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES. © 2014 Springer-Verlag Berlin Heidelberg.
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    The role of mast cells in vascularized recurrent pterygium
    (Conselho Brasileiro De Oftalmologia, 2014) Celebi A.R.C.; Özbey, Caner; Mirza G.E.
    Objective: To determine and compare the mast cell count in primary and recurrent vascularized pterygium, and in normal bulbar conjunctiva. Methods: The study included 22 patients with primary pterygium (PP group) and 28 patients with vascularized recurrent pterygium (VRP group) that underwent excision via the limbal conjunctival autograft technique. Normal conjunctiva samples were collected from the superotemporal bulbar conjunctival region, just temporal to the site from which the autograft conjunctival tissue was harvested. The total number of mast cells in the pterygium (primary and recurrent) and control tissue samples was calculated microscopically using 1% toluidine blue stain under 400× magnification. Results: The mean mast cell count in primary and vascularized recurrent pterygium tissue was 7.45 ± 2.06 mm-2 and 16.11 ± 4.33 mm-2, respectively, and the difference was significant (independent samples t-test, P<0.001). The mean mast cell count in pterygium tissue was significantly higher than that in normal conjunctiva tissue in both groups (Student's t-test, P<0.001). Conclusion: An increase in the number of mast cells might play a role in the pathogenesis of recurrent pterygium. Determination of a mast cell count cut-off value could be of diagnostic significance for recurrent pterygium.