Age-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
PURPOSE. We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SDOCT) in healthy individuals. METHODS. In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear regression analysis and Spearman's correlation analysis were performed to investigate the level of difference in age-related change in the overall mean, 4 quadrants mean, and 12 clock-hour sectors mean RNFLT. RESULTS. Mean age of the 121 healthy participants was 39 years (range, 20-59 years). Mean 4 quadrant and mean 12 clock-hour sector RNFLT in the 121 randomly selected eyes in 121 healthy participants decreased significantly with age in the overall group (Spearman's correlation analysis, P < 0.05). Overall mean RNFLT decreased by 0.365 lm (95% confidence interval [CI], 0.47-0.26; linear regression analysis, P < 0.001) for every one year increase in age. Overall, the greatest decrease in mean RNFLT was in the lower quadrant (0.575 lm/y; 95% CI, 0.733-0.416), versus the least decrease in the nasal quadrant (0.141 lm/y; 95% CI, 0.272-0.010), and the greatest decrease in mean RNFLT was in the 6 clock-hour sector (0.656 lm/y; 95% CI, 0.939-0.374), versus the least decrease in the 3 clock-hour sector (0.119 lm/y; 95% CI, 0.266-0.029). CONCLUSIONS. Age-related decrease in RNFLT varied according to sector. Age-related change should be accounted for in any assessment of RNFLT. Regional age-related change is accounted for by Cirrus SD-OCT in its normative database.© 2013 The Association for Research in Vision and Ophthalmology, Inc.
Açıklama
Anahtar Kelimeler
Age, Change, Retinal nerve fiber layer, Spectral domain optical coherence tomography
Kaynak
Investigative Ophthalmology and Visual Science
WoS Q Değeri
Scopus Q Değeri
Cilt
54
Sayı
13
