Age-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography

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dc.contributor.authorCelebi A.R.C.
dc.contributor.authorMirza G.E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractPURPOSE. We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SDOCT) in healthy individuals. METHODS. In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear regression analysis and Spearman's correlation analysis were performed to investigate the level of difference in age-related change in the overall mean, 4 quadrants mean, and 12 clock-hour sectors mean RNFLT. RESULTS. Mean age of the 121 healthy participants was 39 years (range, 20-59 years). Mean 4 quadrant and mean 12 clock-hour sector RNFLT in the 121 randomly selected eyes in 121 healthy participants decreased significantly with age in the overall group (Spearman's correlation analysis, P < 0.05). Overall mean RNFLT decreased by 0.365 lm (95% confidence interval [CI], 0.47-0.26; linear regression analysis, P < 0.001) for every one year increase in age. Overall, the greatest decrease in mean RNFLT was in the lower quadrant (0.575 lm/y; 95% CI, 0.733-0.416), versus the least decrease in the nasal quadrant (0.141 lm/y; 95% CI, 0.272-0.010), and the greatest decrease in mean RNFLT was in the 6 clock-hour sector (0.656 lm/y; 95% CI, 0.939-0.374), versus the least decrease in the 3 clock-hour sector (0.119 lm/y; 95% CI, 0.266-0.029). CONCLUSIONS. Age-related decrease in RNFLT varied according to sector. Age-related change should be accounted for in any assessment of RNFLT. Regional age-related change is accounted for by Cirrus SD-OCT in its normative database.© 2013 The Association for Research in Vision and Ophthalmology, Inc.
dc.identifier.doi10.1167/iovs.13-12634
dc.identifier.endpage8103
dc.identifier.issn0146-0404
dc.identifier.issue13
dc.identifier.pmid24194190
dc.identifier.startpage8095
dc.identifier.urihttps://dx.doi.org/10.1167/iovs.13-12634
dc.identifier.urihttps://hdl.handle.net/11480/797
dc.identifier.volume54
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofInvestigative Ophthalmology and Visual Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAge
dc.subjectChange
dc.subjectRetinal nerve fiber layer
dc.subjectSpectral domain optical coherence tomography
dc.titleAge-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography
dc.typeArticle

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