Yazar "Destegul, Dilek" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Adult Tetanus With Fatal Course: A Case Report(Aves, 2019) Arslan-Gulen, Tugba; Destegul, Dilek; Ortakoylu-Kilickaya, Refika; Imre, Ayfer; Atan-Ucar, Zuhal; Kayabas, UnerDespite improvements in medicine, tetanus is still a fatal infectious disease which can be prevented by immunoprophylaxis and it should always be kept in mind after injuries. In this case report, we present a patient who had no previous immunization history and did not have tetanus prophylaxis completed at the first visit of the emergency department after injury. The patient was followed with a clinical picture of generalized tetanus in intensive care unit, but autonomic dysfunction could not be taken under control despite treatment and resulted in mortality. Tetanus prophylaxis should be questioned in patients applying with injury or trauma. Strategies should be developed in order to achieve regular vaccination, with respect to adult immunization in particular.Öğe Anesthetic management of two siblings with congenital insensitivity to pain with anhidrosis syndrome(Kare Publ, 2019) Destegul, Dilek; Kocaoz, Fazilet; Sari, Ahmet SinanCongenital insensitivity to pain with anhidrosis (CIPA) is a rare syndrome characterized by a lack of sensitivity to pain due to congenital sensory and autonomic neuropathies, anhidrosis, an inability to regulate body temperature, growth retardation, mental retardation at different levels of severity, and inadvertent self-harm. It is an autosomal recessive disorder that is result of a mutation in the neurotrophic receptor tyrosine kinase 1 gene, which encodes neurotrophic tyrosine kinase. CIPA patients are frequently admitted to hospitals with unrecognized traumatic fractures and unhealed wounds due to the lack of a pain response. Presently described is the method of anesthetic management used for 2 siblings, aged 17 and 14 years, with a generalized lack of pain, anhidrosis, mental retardation, and septic arthritis. Sedation with midazolam alone provided satisfactory surgical comfort without causing hemodynamic instability in these 2 patients with CIPA syndrome.Öğe Effect of Sugammadex on Coagulation Parameters in Cesarean Section Patients a Prospective Controlled Observational Study(Aves, 2021) Destegul, Emre; Destegul, Dilek; Kocaoz, FaziletObjective: To evaluate, for the first time in the literature, the effect of sugammadex in elective C/S patients in terms of hemostatic parameters and postoperative bleeding. Methods: Seventy-six patients enrolled for this observational prospective controlled study. Patients were divided into two groups according to anesthetic reversal agent: sugammadex (group I) vs neostigmin (group II). Intraoperative and postoperative amount of bleeding were recorded. At the end of the surgery, after administration of reversal agent, and at postoperative 30th minute, 1st, and 2nd hours, activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR) values were recorded. Postoperative Hct, Hgb, and Plt values at 6th and 24th hours of reversal agent administration were also recorded. Results: Alterations in aPTT, PT, and INR values were similar between the groups (P = .986, .549, .05, respectively). Conclusion: Sugammadex at 2 mg kg(-1) in cesarean section patients has a similar effect on coagulation parameters compared to neostigmin. Further studies are needed particularly in patients under thromboprophylaxis.Öğe Retrospective Evaluation of Critical Care Patients with Upper Gastrointestinal System Bleeding(Turkish Soc Medical & Surgical Intensive Care Medicine, 2019) Ozkan Kuscu, Ozlem; Elmas, Dursun; Erdogan, Murat; Arslan Benli, Burcu; Karaogcullarindan, Umit; Aktay Inal, Meltem; Destegul, DilekAim: Upper gastrointestinal bleeding is an important cause of mortality and morbidity. The aim of this study is to evaluate the risk factors of mortality in patients admitted to medical ICU with upper gastrointestinal bleeding. Methods: Patients admitted to medical ICU with upper GI bleeding or patients with new onset GIS bleeding during the ICU stay between January 2010- December 2016 were included. Patient datas were recorded from the hospitals database retrospectively. Results: There were 3990 patients between the study period. One hundred seventy six of these patients had gastrointestinal bleeding and enrolled the study. One hundred seventeen (66,5%) of 176 patients were male, 59 (33,5%) were female. Mean age of the patients was 63 +/- 16 years. While the number of the patients who underwent endoscopy procedure was 152 (86,4%); mortality rate of these patients was 46,1%; and 91,7% for the patients who did not undergo the endoscopy procedure. Mortality rates of patients with variceal and nonvariceal bleeding diagnose were 46% and 47,6%. Uremia, renal failure, increase of the leucocyte count during the follow up, coagulopathy, increased demand of erythrocyte suspension and lack of endoscopy procedure were determined as risk factors for mortality. Conclusion: Upper gastrointestinal bleeding in the intensive care unit is a situation which is with high mortality rate. Higher APACHE II Score, presence of comorbidities are determinants of prognosis.Öğe The Identification of Intracellular Signalling Pathway Through DHMGB1/TLR2 Axis on Myocardial Ischemia/Reperfusion Injury-Induced Apoptosis(Wiley, 2022) Guven, Eylem Taskin; Guven, Celal; Kaya, Salih Tunc; Keles, Ayse Ikinci; Destegul, Dilek; Pelit, Aykut; Gunay, Ismail[Abstract Not Available]
