Yazar "Gunturk, Inayet" seçeneğine göre listele
Listeleniyor 1 - 20 / 21
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe ANGIOGENIC REGULATORS DURING ALPINE SKIING TRAINING(Dokuz Eylul Univ Inst Health Sciences, 2024) Polat, Metin; Gunturk, Inayet; Demiryurek, DuranPurpose: The present study evaluates angiogenesis response through the determination of acute changes in hypoxia inducible factor 1 alpha, vascular endothelial growth factor, erythropoietin and endostatin levels measured after a single-session slalom and giant slalom trainings. Material and Methods: A total of 20 volunteer male athletes average age of 22.16 +/- 4.86 years with no health problems, and with international alpine skiing competition experience were included in the study. At the outset, the height, body weight and VO2max values of the volunteers was measured, and a giant slalom training lasting 2.5 hours was performed after a week on a giant slalom course. The volunteers were then asked not to exercise for a week, and slalom training was performed lasting 2.5 hours on a slalom course. The endostatin, erythropoietin, hypoxia inducible factor 1 alpha, and vascular endothelial growth factor levels of the volunteers were examined from 5 ml venous blood samples drawn into biochemistry tubes 20 minutes before and as soon as trainings over both the giant slalom and slalom Results: A significant increase was determined in the hypoxia inducible factor 1 alpha, vascular endothelial growth factor, erythropoietin and endostatin levels after both the giant slalom and slalom Conclusion: These increases observed in the angiogenesis markers suggests that a single-session giant slalom and slalom trainings induces angiogenesis responses.Öğe Are follistatin-like protein 1 and follistatin-like protein 3 associated with inflammatory processes in patients with familial Mediterranean fever?(Kare Publ, 2023) Kaplan, Huseyin; Calis, Mustafa; Yazici, Cevat; Gunturk, Inayet; Cuce, Isa; Senel, Abdurrahman SonerOBJECTIVE: Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF. METHODS: Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted. RESULTS: Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05). CONCLUSION: Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.Öğe Assessment of the Relationship Between the Adropin Levels and the Coronary Collateral Circulation in Patients with Chronic Coronary Syndrome(Arquivos Brasileiros Cardiologia, 2022) Akkaya, Hasan; Gunturk, Ertugrul Emre; Akkaya, Fulya; Karabiyik, Ugur; Gunturk, Inayet; Yilmaz, SametBackground: Coronary collateral circulation (CCC) provides an alternative blood flow to myocardial tissue exposed to ischemia and helps to preserve myocardial functions. Endothelial-derived nitric-oxide (NO) production and vascular endothelial growth factor (VEGF) have been suggested as the most important factors in the development of CCC. Adropin is a peptide hormone responsible for energy hemostasis, and is known for its positive effects on the endothelium through NO and VEGF. Objective: The aim of this study is to investigate the association between adropin and the presence of CCC in patients with chronic coronary syndrome (CCS). Methods: A total of 102 patients with CCS, who had complete occlusion of at least one major epicardial coronary artery, were included in the study and were divided into two groups: the group of patients (n:50) with poor CCC (Rentrop 0-1) and the group of patients (n:52) with good CCC (Rentrop 2-3). The level of significance adopted in the statistical analysis was 5%. Results: Mean adropine levels were found as 210.83 +/- 17.76 pg/mL and 268.25 +/- 28.94 pg/mL in the poor and good CCC groups, respectively (p<0.001). Adropin levels proved to be positively correlated with neutrophil-to-lymphocyte ratios (r:0.17, p:0.04) and the rentrop scores (r:0.76, p<0.001), and negatively correlated with age (r:-0.23, p:0.01) and Gensini scores (r:-0.19, p:0.02). Adropin level is a strong independent predictor of good CCC development (OR:1.12, 95% CI:(1.06-1.18), p<0.001). Conclusion: This study suggests that adropin levels may be a possible factor associated with the presence of CCC in CCS patients.Öğe Effect of N-acetylcysteine on cisplatin induced apoptosis in rat kidney(Cukurova Univ, Fac Medicine, 2022) Gunturk, Inayet; Seydel, G. Seyda; Dagli, Fatma; Yay, Arzu; Yazici, Cevat; Kose, KaderPurpose: Cisplatin is one of the most potent and widely used chemotherapeutic agents for the treatment of a wide variety of solid organ cancers. However, due to various side-effects such as nephrotoxicity, its therapeutic applications are limited. In the current study, it was aimed to investigate the effects of N-acetylcysteine (NAC), which is an effective antioxidant and anti-inflammatory agent, on cisplatin-induced apoptosis in rat kidneys. Materials and Methods: Twentyfour male Wistar rats were separated into 4 equal groups: Control, NAC-250, cisplatin (CP), and CP+NAC groups. Rats in the experimental groups were treated with intraperitoneally (i.p.) single-dose cisplatin (10 mg/kg) and NAC (i.p., 250 mg/kg) for 3 days. Results: At the end of the experiment, nephrotoxicity was confirmed by blood urea nitrogen and creatinine levels, and the apoptotic changes were demonstrated by TdT-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) and caspase-3 levels in rat kidneys. The number of TUNEL-positive cells and caspase-3 levels were significantly increased by cisplatin. Treating the rats with NAC significantly decreased TUNEL-positive cells and caspase-3 levels. Conclusion: These data suggest that apoptotic cell death is involved in the pathogenesis of cisplatin-induced nephrotoxicity, and that the inhibition of apoptosis plays a central role in the beneficial effects of NAC.Öğe Effects of thymoquinone in prevention of experimental contrast-induced nephropathy in rats(Mashhad Univ Med Sciences, 2019) Topaloglu, Ulan Serkan; Sipahioglu, Murat Hayri; Gunturk, Inayet; Akgun, Hulya; Dogan, Muhammet Ensar; Sonmez, Gokhan; Elmali, FerhanObjective(s): This study aimed to show the effects of thymoquinone, which is known for its antioxidant, anti-inflammatory, and renal protective effects in contrast-induced nephropathy. Materials and Methods: This is an experimental study in rats. 7 groups were included within the scope of our study: sham-vehicle (n=3), premedication-control (n=6), model (n=6), isolated thymoquinone (n=3+3), low-dose thymoquinone (n=6), and high-dose thymoquinone (n=7). In addition to 48 hr of water deprivation, we pre-medicated the rats with intra-peritoneal indomethacin and L-NAME administration. After premedication, 12.5 ml/kg dose of a high osmolar contrast agent-diatrizoat (Urografin %76) was administrated. Thymoquinone was administrated in two different doses of 1 mg/kg and 1.75 mg/kg for four days intraperitoneally. Renal functions, histopathological differences, oxidative stress parameters, and inflammatory indicators of rats were evaluated at the end of the study. Results: Significant decreases were observed in levels of serum creatinine and serum BUN with low-dose thymoquinone (1 mg/kg) administration. In light microscopy, significantly less histopathological damage was observed in the low-dose thymoquinone group compared to the contrast agent group. While high-dose thymoquinone is accepted as ineffective biochemically, toxic evidence was identified histopathologically. There were no significant differences between M and TA groups for serum MDA and SOD levels, which were compared to evaluate oxidative stress (P:0.99, P:0.98; respectively). TNF-alpha, iNOS, and NF-kappa B gene expressions were not significantly different between all groups (P:0.748, P:0.531, P:0.910; respectively). Conclusion: This experimental study has demonstrated for the first time the protective effect of the TQ substance for CIN in 1 mg/kg dose, in the accompaniment of biochemical and histopathological data in rats.Öğe EVALUATION OF OXIDATIVE STRESS, 3-NITROTYROSINE, AND HMGB-1 LEVELS IN PATIENTS WITH WET TYPE AGE-RELATED MACULAR DEGENERATION(Soc Medical Biochemists Serbia, 2022) Zor, Kursad Ramazan; Sari, Ismail; Bicer, Gamze Yildirim; Gunturk, Inayet; Kucuk, Erkut; Ersan, Serpil; Seydel, Gonul SeydaBackground: This study aims to compare serum HMGB-1, 3-nitrotyrosine (3-NT), TAS, TOS, and OSI levels in Wettype Age-Related Macular Degeneration (wAMD) patients and healthy controls to determine the correlation of these parameters with each other. Methods: Thirty patients with Wet-type Age-Related Macular Degeneration (wAMD) and 27 healthy adults, as controls were enrolled in the study. We determined the TAS and TOS levels in serum samples of both groups using commercial kits on a microplate reader. Serum HMGB-1 and 3-NT levels were measured with the enzyme-linked immunosorbent assay method. Results: HMGB-1 levels were significantly higher in the patient group (137.51 pg/mL, p=0.001), while there was no difference between the two groups in serum 3-NT levels (p = 0.428). A statistically significant difference found in the levels of TOS and OSI (p = 0.001 and p = 0.045, respectively) between the patients and controls, however, no significant difference was observed between the groups in terms of TAS levels (p = 0.228). Conclusions: Oxidative stress and HMGB-1 levels were increased in wAMD patients and enhanced oxidative stress may be associated with increased tissue necrosis and inflammation. Thus administration of antioxidant treatment in addition to routine therapy should be considered in wAMD.Öğe Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism(Cukurova Univ, Fac Medicine, 2022) Dagli, Fatma; Gunturk, Inayet; Seydel, Gonul Seyda; Yazici, CevatPurpose: This study aims to investigate the effects of experimental hyperthyroidism and carnosine which is known to have antioxidant properties on physical and vital findings in rats, and to determine the relationship between these parameters and free T3 (FT3) levels. Materials and Methods: Rats were analyzed in 7 groups (each containing 12 animals); control (CONT), hyperthyroidism-1 (T:10-day L-thyroxine (L-T4) administration), hyperthyroidism-2 (T-T: 20-day L-T4 administration), Carnosine (10 day carnosine administration), Hyperthyroidism-1 + Carnosine (T-C), Hyperthyroidism-2 + Carnosine (T-TC), and Carnosine + Hyperthyroidism-1 (C-T). In order to create a hyperthyroidism model, L-thyroxine (L-T4) doses of 300 mu g/kg rat weight/day and carnosine doses of 300 mu g/kg rat weight/ day were intraperitoneally (ip) administered to the rats. Results: After 10 and 20 days of thyroxine administration, FT3 levels (T:3.64 +/- 0.51pg/mL, T-T: 4.06 +/- 0.91pg/mL) and body temperature (T:37.1 +/- 0.3oC, T-T: 37.6 +/- 0.3oC), significantly increased while body weight decreased (T:240.7 +/- 22.0g, T-T:263 +/- 0.28.7g). Carnosine administration only prevented the increase of FT3 levels, but had no effect on other parameters. Conclusion: The increased FT3 levels observed with LT4 administration were consistent with the physical and vital findings, but carnosine administration did not reflect the expected effects on the physical findings observed in the hyperthyroid condition.Öğe Evaluation of the relationship between disease severity and the leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients(Bayrakol Medical Publisher, 2024) Seydel, Gonul Seyda; Gunturk, Inayet; Yazici, Cevat; Topaloglu, Ulas Serkan; Eren, Esma Eryilmaz; Yuksel, Recep CivanAim: Overweight and obesity are substantial risk factors in the severity of COVID-19 disease. This study aimed to assess the relationship between the disease severity and leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients. Material and Methods: The study involved 60 COVID-19 patients (patient group) and 30 healthy controls with BMI >= 25. The patient group was split into two subgroups based on disease severity (30 mild/moderate and 30 severe/critical patients). The levels of leptin, adiponectin, and chemerin in plasma were determined using the ELISA technique. Results: Our study revealed that leptin levels were considerably increased in both groups of COVID-19 patients compared to the healthy controls, while chemerin levels were decreased. In adiponectin levels, there was no statistically significant difference between the groups. Discussion: Plasma leptin and chemerin levels are associated with the progression and/or severity of disease in overweight and obese COVID-19 patients.Öğe Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels(Bmj Publishing Group, 2020) Tekin, Tuba; Cicek, Betul; Konyaligil, Nurefsan; Gunturk, Inayet; Yazici, Cevat; Karaca, Zuleyha; Unlusavuran, MeltemBackground This case-control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome. Methods Thirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting. Results Serum nesfatin-1 levels were 0.245 +/- 0.272 ng/mL in the case group and 0.528 +/- 0.987 ng/mL in the control group (p>0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p<0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p<0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p<0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p<0.05). Conclusions Anthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.Öğe Investigation of Left Atrial Spontaneous Echo Contrast as a Marker Indicating Ineffective Anticoagulation in Patients with Mitral Valve Replacement Receiving Warfarin(2019) Gunturk, Ertugrul Emre; Demirbas, Melih; Dogan, Yasemin; Dogan, Selcuk; Gunturk, InayetObjectives: This study aimed to evaluate predictive role of left atrial (LA) spontaneous echo contrast (SEC) for ineffec-tive anticoagulation by assessing time in therapeutic range (TTR) via international normalized ratio (INR) monitoring in patients with mitral valve replacement (MVR) and to determine its relationship with increased thromboembolic events.Methods: The study included patients with mechanical MVR. TTR was estimated using serial INR measurements. On transthoracic echocardiography, left ventricular end-systolic/end-diastolic diameters, LA diameter, ejection fraction were measured, and the presence of SEC was determined.Results: The study included 65 patients with MVR (30 with LA SEC) and 35 without LA SEC. There was a trend for higher rates of cerebrovascular event in the patients with SEC than in those without (30% vs. 14.3%, p=0.046). The LA diameter was higher and the TTR was lower in the patients with SEC than in those without. There was a significant negative cor-relation between TTR and thromboembolic events. Multivariable logistic regression analysis revealed the TTR and LA diameter as independent factors affecting SEC.Conclusion: In patients with MVR, low TTR and enlarged left atrium were independent predictors for future throm-boembolic events. Monitoring INR is important to achieve higher TTR in the presence of LA SEC.Öğe IS THER ANY ROLE OF THE URINE DICKOPPF-3/CREATININE RATIO IN EARLY DETECTION OF ACUTE KIDNEY INJURY IN PEDIATRIC INTENSIVE CARE UNIT?(Springer, 2022) Gokceli, Sefa Armagan; Gunay, Neslihan; Gunturk, Inayet; Dundar, Mehmet Akif; Akyildiz, Basak Nur; Yazici, Cevat; Yel, Sibel[Abstract Not Available]Öğe Prevalence of Hemoglobinopathies in Premarital Screening in the Province of Nigde, Turkey(Taylor & Francis Ltd, 2023) Seydel, Gonul Seyda; Ayan, Durmus; Balci, Tevfik; Bayraktar, Muhammet; Gunturk, InayetHemoglobinopathies are one of the most widespread hereditary disorders in Turkey. The present study aimed to determine the prevalence of hemoglobinopathies in the Nigde province of Turkey. This study was conducted with 2013 individuals who applied for the premarital screening, between January 2019 and December 2021. The complete blood count was measured by an automated hematology analyzer. The types of hemoglobin were determined by high-performance liquid chromatography. A total of 2013 individuals including 951 (47.2%) females and 1062 (52.8%) males, were screened within the premarital screening program, and 67 (3.3%) of them were migrants. 53 out of 2013 (2.63%) individuals were identified as beta thalassemia carriers, and five of them were migrants including two from Afghanistan, two from Iran, and one from Georgia. HbC was observed in two cases, a couple from Syria (0.1%), HbD in two cases (0.1%), HbE in one case from Thailand (0.05%), HbS-beta-thalassemia in one case (0.05%), delta-beta thalassemia in one case (0.05%), and unidentified structural variant in one case (0.05%). Moreover, 183 individuals (9.1%) were considered to have iron deficiency, alpha-thalassemia, or silent beta-thalassemia carrier. These results indicate that the province of Nigde is a relatively risky region regarding hemoglobinopathies. Geographic location and immigrant population may have slightly affected the local prevalence of hemoglobinopathies and could be taken into consideration to ensure the effective implementation of the hemoglobinopathy prevention program.Öğe Response to chronic sustained hypoxia: increased cytosolic gelsolin and decreased plasma gelsolin levels(Springer, 2024) Gunturk, Inayet; Kuloglu, Nurhan; Seydel, Gonul Seyda; Yazici, Cevat; Basaran, Kemal Erdem; Yakan, Birkan; Karabulut, DeryaAn actin binding protein, gelsolin (GSN) has two isoforms, plasma (pGSN) and cytosolic (cGSN). Changes in pGSN and/or cGSN levels have been shown to be associated with the pathogenesis of several diseases. The aim of this study was to evaluate changes in intracellular and extracellular GSNlevels with HIF-1 in animals exposed to chronic sustained hypoxia (CSH), in addition to apoptosis and the cellular redox status. The rats in the Sham group were exposed to 21% O-2, and the rats in the hypoxia groups were exposed to 13 and 10% O-2, respectively. Plasma pGSN, HIF-1 alpha, Total Antioxidant Status (TAS) and Total Oxidant Status (TOS), and lung tissue pGSN, HIF-1 alpha, TAS, TOS, GSN levels, and apoptotic cell numbers were measured. HIF-1 alpha levels were found to increase significantly in the tissue, especially in the group with severe hypoxia, both in biochemical and histological examinations. pGSN levels were also significantly decreased in both plasma and tissue. Significant increases in tissue were observed in cGSN. It was observed that while the antioxidant activity was dominant in the tissue, the oxidant activity was dominant in the plasma. In particular, the response to hypoxia regulated by HIF-1 is very important for cellular survival. The results of this study showed that the increase in cGSN and TAS levels in the lung tissue together with HIF-1 alpha can be considered as the activation of mechanisms for cellular protection.Öğe Serum interleukin-18 levels are associated with non-dipping pattern in newly diagnosed hypertensive patients(Lippincott Williams & Wilkins, 2021) Gunturk, Ertugrul Emre; Gunturk, Inayet; Topuz, Ayse Nur; Akkaya, Hasan; Topuz, MustafaBackground Interleukin-18 (IL-18), a pro-inflammatory cytokine, increases inflammation in the endothelium. Increased inflammation plays an important role in the development of hypertension (HT). IL-18 level is higher in hypertensives than normotensives. Objective To investigate the relationship between IL-18 level and diurnal blood pressure (BP) variations in newly diagnosed HT patients. Methods This prospective study included 130 subjects referred to outpatient cardiology clinic with an initial diagnosis of HT. The patients were classified as dipper HT (n = 40), non-dipper HT (n = 50), and normotensive (control, n = 40) according to 24-hour ambulatory BP monitoring. All subjects underwent blood sampling after 12 hours of fasting and transthoracic echocardiography. Results The serum IL-18 level was significantly higher in the patient group compared with the controls (195.17 +/- 93.00 mg/dl vs. 140.75 +/- 71.11 mg/dl, P < 0.01) and also in the non-dipper group than in the dipper group (217.3 +/- 96.90 mg/dl, 167.5 +/- 80.79 mg/dl, P = 0.011). IL-18 level was positively correlated both the night-time SBP and DBP levels (r = 0.29, P = 0.02 and r = 0.34, P < 0.01, respectively). On multivariate linear regression analysis, left atrium diameter, left ventricular mass index, and serum IL-18 level were independent predictors of non-dipping pattern in newly diagnosed HT patients. Conclusion Higher IL-18 level was particularly associated with an increase in the night-time BP levels. IL-18 can be used as a predictor for non-dipper HT in newly diagnosed HT patients.Öğe Serum visfatin levels are positively correlated with dietary carbohydrate and polyunsaturated fatty acid intakes in type 2 diabetes mellitus patients(Elsevier Science Inc, 2023) Ozturk, Nurefsan Konyaligil; Cicek, Betul; Tekin, Tuba; Gunturk, Inayet; Yazici, Cevat; Karaca, Zuleyha; Sonmez, MeltemAims: To investigate the relationship between dietary intake and biochemical parameters and anthropometric measurements and serum visfatin concentrations. Study design: A case-control study. Methods: The study was carried out in 30 type 2 diabetes mellitus (T2DM) and 30 sex, age and body mass index (BMI) matches healthy control subjects. Biochemical parameters (glycemic and lipid profile, insulin resistance), anthropometric measurements (weight and bioimpedance) and dietary intake evaluation were obtained. Visfatin was assayed with ELISA method. Results: The mean BMI of the case group was 31.36 +/- 4.37 kg/m(2) and 29.80 +/- 3.53 kg/m(2) in the control group (p = 0.134). The results revealed a significant increase in the weight, waist circumference, waist/hip ratio, visceral fat ratio, fasting glucose level, HbA1c and fasting insulin as well as in insulin resistance (HOMA-IR) among T2DM patients when compared with controls (p < 0.05). Serum visfatin levels were higher in the subjects with T2DM than healthy control subjects (p < 0.05). There was no significant correlation between visfatin levels and biochemical parameters and anthropometric measurements in patients with T2DM. Serum visfatin level was positively correlated with carbohydrate (CHO) and polyunsaturated fatty acid (PUFA) in T2DM patients (r = 0.406, p = 0.026; r = 0.404, p = 0.027, respectively). Conclusion: T2DM patients compares with healthy control group increased serum visfatin levels. PUFA and CHO intake was found to be positively associated with visfatin levels.Öğe The effect of acute step-aerobic exercise on adiponectin and leptin levels in premenopausal women(Edizioni Minerva Medica, 2021) Sari, Ismail; Habipoglu, Sedef; Seydel, G. Seyda; Ersan, Serpil; Gunturk, InayetBACKGROUND: It is well known that the prevalence of obesity, cardiovascular disease and metabolic syndrome is increasing during the transition to menopausal stages. The aim of this study was to investigate the effects of acute step-aerobic exercise on levels of leptin and adiponectin, which are adipose tissue-derived adipocytokines, associated with obesity, hypertension and other diseases in sedentary premenopausal women. METHODS: Twenty-four sedentary premenopausal volunteer women between the ages of 40-45 (premenopause group) and 24 healthy adults between the ages of 21-39 (control group) were enrolled in this study. Moderate intensity step-aerobic exercise (50-60% of HRmax) was applied for 60 min to the premenopausal subjects. Venous blood samples were obtained before and after the exercise. Adiponectin and leptin levels were determined using the ELISA method. RESULTS: No statistically significant difference was found in terms of BMI values, and leptin levels between the premenopause and control group, while differences of adiponectin were statistically significant. Plasma leptin levels of the premenopausal women decreased whereas adiponectin levels increased meaningfully after the acute aerobic exercise (P<0.05). When the premenopausal women were grouped according to BMI, there were no significant differences between BMI <= 30 and >30 groups in terms of leptin and adiponectin levels measured before and after exercise. CONCLUSIONS: Our results may suggest that acute step aerobic exercise in premenopausal women alters leptin and adiponectin levels in favor of the organism. However, further studies are needed.Öğe The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model(Tubitak Scientific & Technological Research Council Turkey, 2019) Gunturk, Inayet; Yazici, Cevat; Kose, Kader; Dagli, Fatma; Yucel, Bilal; Yay, ArzuBackground/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental groups were treated intraperitoneally (i.p.) with a single dose of cisplatin (10 mg/kg body weight) and i.p. with NAC (250 mg/kg body weight) for three consecutive days. Nephrotoxicity was determined by plasma BUN and creatinine levels. In tissue samples, myeloperoxidase (MPO), nuclear factor-kappa B (NF-kB), high mobility group box-1 (HMG B-1), total oxidant status (TOS), and total antioxidant status (TAS) levels were measured. Kidneys were analyzed histopathologically as well. Results: It was revealed that cisplatin was not effective on MPO, HMGB-1 and NF-kB levels but did increase TOS levels and decrease TAS levels in tissue samples. Interestingly, NAC elevated MPO and HMGB-1 levels significantly. Nevertheless, NAC ameliorated histological and functional changes in kidney tissues. Conclusion: It is suggested that inflammation has a limited effect on cisplatin nephrotoxicity in this experimental design, and, as reflected by decreased BUN and creatinine levels, NAC can be used as an additional therapeutic agent in standard cisplatin treatment protocols.Öğe The Effects of Sex Hormones on Postoperative Pain in Patients with Laparoscopic Cholecystectomy(Lippincott Williams & Wilkins, 2024) Koras Sozen, Kezban; Bolat, Haci; Gunturk, InayetObjective: There are many factors that affect postoperative pain. This study determines the effect of preoperative sex hormone levels on postoperative pain levels in patients undergoing laparoscopic cholecystectomy. Patients and Methods: This study included a total of 89 patients who met the study inclusion criteria. The patients were divided into 3 groups based on their sex and pre and postmenopausal periods: male patients (n = 28), postmenopausal female patients (n = 31), and female patients with normal cycles (n = 30). Normal-cycle women were also regrouped based on their follicular and luteal phases. Data were collected using a descriptive characteristics form, a patient follow-up form, and the Visual Analog Scale. Results: Venous blood samples taken from the patients before surgery were used to measure their levels of estradiol (EST), testosterone (TES), and progesterone levels. Male patients had lower pain levels than female patients. The male patients' Visual Analog Scale scores were inversely related and correlated strongly with their TES levels (P < 0.05). However, subgroup analyses suggested that their EST level played a primary role in males and that the EST/TES ratio was determinant in the late postoperative period. In female patients, the EST/progesterone ratio was the most determining factor for the level of pain felt in the postmenopausal period, whereas there was no change in the premenopausal period at different stages of the menstrual cycle. Conclusions: Sex hormones were found to be effective in predicting postoperative pain severity.Öğe The Relationship Between Plasma Gelsolin Levels and Myeloperoxidase in Patients Undergoing Hemodialysis: A Prospective, Observational, Controlled Study(Erciyes Univ Sch Medicine, 2024) Tural, Haci Huseyin; Kose, Kader; Gunturk, Inayet; Kocyigit, Ismail; Yazici, CevatObjective: Given the association of inflammatory conditions with the development of comorbidities, particularly cardiovascular diseases, it is crucial to monitor inflammation in hemodialysis patients. This study aimed to evaluate plasma gelsolin and myeloperoxidase (MPO) levels before and after dialysis sessions and to assess their relationship with inflammation. Materials and Methods: The study included 16 healthy volunteers and 30 patients receiving regular hemodialysis treatment. Along with routine biochemical analyses, plasma gelsolin and MPO levels were measured in blood samples taken from the study group before and after the sessions. Results: Plasma gelsolin levels were found to be statistically higher both before and after dialysis compared to the control group (p=0.000); however, there was no significant change during the session (p=0.094). Conversely, plasma MPO activity, which was significantly higher before dialysis, increased at the end of the session (p=0.000). Conclusion: It can be concluded that elevated levels of gelsolin are associated with a chronic inflammatory response, as indicated by high -sensitivity C -reactive protein (hsCRP) and MPO levels. Consequently, gelsolin could be considered a supportive treatment strategy for these patients.Öğe The relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome(Taylor & Francis Ltd, 2024) Seydel, Gonul Seyda; Gunturk, Inayet; Akkaya, Hasan; Gunturk, Ertugrul EmreBackgroundInflammation plays a crucial role in the progression of acute coronary syndrome.AimsThe aim of this study was to investigate the relationship between the SYNTAX score and new inflammatory markers including albumin-globulin ratio (AGR), C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), and neutrophil percentage-to-albumin ratio (NPAR) in STEMI and NSTEMI patients.MethodsThe study involved 53 STEMI and 64 NSTEMI patients, and each patient group was evaluated separately. Multivariate linear regression analysis was utilised to identify independent risk factors associated with SYNTAX scores.ResultsOut of the 64 NSTEMI patients, 42 had low SYNTAX score (65.6%), and 22 had high SYNTAX score (34.4%). Patients with high SYNTAX scores had significantly higher levels of age, glucose, fibrinogen, monocyte, and FAR, and lower levels of albumin and total protein. We found that FAR and monocyte levels were independent predictors of the high SYNTAX score. The study also determined that the cut-off value for FAR as 9.99, with a sensitivity of 81% and a specificity of 73% for predicting high SYNTAX score in NSTEMI patients. Out of the 53 STEMI patients, 42 had low SYNTAX score (79.2%), and 11 had high SYNTAX score (20.8%). Patients with high SYNTAX scores exhibited significantly higher total cholesterol, LDL, and glucose levels, and lower albumin and total protein levels.ConclusionsThe FAR level is significantly linked with the high SYNTAX score and can be a useful marker for predicting the severity of disease in NSTEMI patients.
