Yazar "Karakaş M.S." seçeneğine göre listele

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    Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease
    (2013) Karakaş M.S.; Altekin R.E.; Baktir A.O.; Küçük M.; Çilli A.; Yalçinkaya S.
    Objectives: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. Platelet activation and aggregation are central processes in the pathophysiology of atherothrombosis. Mean platelet volume (MPV), a determinant of platelet activation, is a newly-emerging risk factor for atherothrombosis. Therefore, we have investigated the possible association between OSAS and MPV. Study design: We selected 30 mild, 32 moderate, and 31 severe OSAS patients and 31 healthy control subjects matched for age, sex, and body mass index. MPV was measured using an automated blood cell counter. Results: The MPV levels were significantly higher in the severe OSA group than in the control group (8.6±1.1 vs. 7.8±0.7 fl, p=0.03). There were no significant differences in respect to MPV between controls and patients with mild and moderate OSA (7.8±0.7 vs. 8.3±1.2 fl, p=0.2; 7.8±0.7 vs. 8.4±1.3 fl, p=0.08) and between patients with mild, moderate, and severe OSA (8.3±1.2 vs. 8.4±1.3 vs. 8.6±1.1 fl, p=0.9). Significant correlations were seen between MPV and apnea-hypopnea index (r=0.347, p?0.001), minimal oxygen saturation (r=-0.224, p=0.03), and the percentage of recording time spent at a oxygen saturation less than 90% (r=0.240, p=0.02). Conclusion: Our results suggest that OSAS patients tend to have relatively increased platelet activation andatherothrombotic risk. © 2013 Turkish Society of Cardiology.
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    Determination of subclinical atherosclerosis in obstructive sleep apnea syndrome patients without traditional risk factors for atherosclerosis [Ateroskleroti·k ri·sk faktörleri· olmayan obstrükti·f uyku apne sendromlu hastalarda subkli·ni·k aterosklerozun saptanmasi]
    (2013) Karakaş M.S.; Altekin R.E.; Özbek S.C.; Yanikoglu A.; Akdemir B.; Er A.; Yalçinkaya A.S.
    Objective: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with high cardiovascular morbidity and mortality. Recent studies have suggested a pathophysiological link between OSAS and atherosclerosis; for which carotid intima-media thickness (CIMT) and pulse wave velocity (PWV) has been considered as an early marker. The aim of this study was to assess the presence of early signs of atherosclerosis and cardiovascular effects of OSAS depending on its severity, in patients without clinically diagnosed cardiovascular disease and any coincident risk factors for atherosclerosis. Material and Method: Thirty one healthy subjects without any systemic disease and OSAS, and patients with OSAS without known atherosclerosis and also without any risk factors for atherosclerosis were examined in the study. According to the severity, 30 patients were in mild OSAS, 32 were in moderate OSAS and 31 patients were in severe OSAS group. Bilateral CIMT assesment and PWV analysis were performed in patients and controls. Results: Significant differences existed between control subjects and patients with mild, moderate and severe OSAS in PWV (5.70±0.48, 6.76±0.61, 7.72±0.82, 8.94±1.72 m/sec respecitively; p<0.0001) and CIMT (0.712±0.040, 0.812±0.037, 0.900±0.056, 0.971±0.74 mm respectively; p<0.0001). AHI and TST% were positively correlated with the following; the PWV (p<0.001- r=0.67 / p<0.001- r=0,70 respectively), the maximal CIMT (p<0.001- r=0.79 / p<0.001- r=0.74 respectively), The minimal SaO2 values were negatively correlated with the following; the PWV (p<0.001, r=-0.66), the maximal CIMT (p<0.001, r=-0.68). Conclusion: OSAS patients have tendency to atherosclerosis development, and this process increases proportionally with the severity of the disease.
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    Determination of subclinical atherosclerosis in plaque type psoriasis patients without traditional risk factors for atherosclerosis
    (Turkish Anaesthesiology and Intensive Care Society, 2012) Altekin E.R.; Koç S.; Karakaş M.S.; Yanikoglu A.; Başarici I.; Demir I.; Alpsoy E.
    Objectives: Systemic inflammation plays an important role in the pathogenesis of atherosclerosis in psoriasis patients. Therefore, persistent skin inflammation in psoriasis patients may contribute to the development of premature atherosclerosis, as it occurs in rheumatoid arthritis and systemic lupus erythematosus. We aimed to evaluate the relationship between subclinical atherosclerosis and psoriasis by using pulse wave velocity (PWV) and the measurement of carotid intima media thickness (CIMT) in psoriatic patients. Study design: Fifty-seven plaque-type psoriasis patients (31 males, 26 females; mean age 41±10.8 years) and 60 healthy individuals (32 males, 28 females; mean age 40±9.4 years) were included. Atherosclerotic risk factors were excluded in both of the groups. Demographic, bio-chemical data, psoriasis area and severity index (PASI) score of the psoriasis group, and disease duration were recorded. Carotid-femoral artery PWV and CIMT values were compared. Results: PWV, and the maximum and average CIMT values of psoriasis patients were higher than those of the healthy group (PWV: 7.04±1.1 m/sn vs. 6.03±0.61 m/sn, p<0.001; maximum CIMT: 0.86±0.09 mm vs. 0.77±0.06 mm, p<0.001; mean CIMT: 0.73±0.09 mm vs. 0.66±0.06 mm p<0.001, respectively). Although there was no difference in the lipid levels of the groups, total/HDL cholesterol (4.40±1.26 vs. 3.88±1.18, p=0.02, respectively), and LDL/HDL cholesterol ratios (2.78±0.98 vs. 2.32±0.92, p=0.01, respectively) of the psoriasis group were higher than those of the healthy group. A positive correlation was observed between PASI and the PWV (r=0.417, p=0.001). Conclusion: Despite the nonexistence of atherosclerotic risk factors, the risk of development of atherosclerosis is higher in psoriasis patients compared to healthy individuals. In addition to damage of the artery wall caused by systemic inflammation, lipid metabolism disorders may contribute to the development of atherosclerosis in these patients. © 2012 Turkish Society of Cardiology.
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    Evaluation of increased subclinical atherosclerosis risk with carotid intima-media thickness and pulse wave velocity in inflamatory bowel disease
    (Turkish Society of Gastroenterology, 2014) Alkan E.; Karakaş M.S.; Yildirim B.
    Background/Aims: A significant increase in accelerated atherosclerosis risk have determined in chronic inflammatory diseases. Recent studies have suggested a pathophysiological link between inflamatory bowel disease (IBD) and atherosclerosis; for which carotid intima-media thickness (CIMT) and pulse wave velocity (PWV) has been considered as an early marker. The aim of this study was to determine the presence of early atherosclerosis in IBD patients without clinically diagnosed cardiovascular disease and any coincident risk factors for atherosclerosis. Materials and Methods: 40 IBD patients who are in remission and without known atherosclerosis and also without any risk factors for atherosclerosis (17 Crohn's disease and 23 ulcerative colitis) and 40 healthy subjects for control group involved in the study. The measurement of bilateral CIMT and carotis-femoral PWV have done in patients and control groups. Results: Significant differences existed between control subjects and patients with IBD in the values of PWV (5.97±0.54 vs. 7.17±0.92 m/sn; p<0.001), maximum CIMT (0.76±0.06 vs. 0.86±0.11mm; p<0.001) and mean CIMT (0.66±0.06 vs 0.74±0.09 mm; p<0.001). In the correlation analysis, a positive correlation has determined between PWV and maximum CIMT and mean CIMT (p<0.001, r=0.75 / p<0.001, r=0.74 respectively). Conclusion: IBD patients have an increased risk of subclinical atherosclerosis than healty controls as showed by greater values of CIMT and PWV. © Copyright 2014 by The Turkish Society of Gastroenterology.
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    Evaluation of renal function in non-hypertensive patients with obstructive sleep apnea [Obstrüktif uyku apne sendromu olan normotansif hastalarda böbrek fonksiyonlari{dotless}ni{dotless}n degerlendirilmesi]
    (2012) Karakaş M.S.; Özbek S.C.; Akdemir B.; Er A.; Yanikoglu A.; Altekin R.E.; Çilli A.
    Objective: Obstructive sleep apnea syndrome (OSAS) is one of the most common sleep disorders in society. The presence of hypertension is shown in 30-60% of OSAS patients. Creatinine clearance (CC) in hypertensive OSAS patients was found to be lower than non-hypertensive OSAS patients. In our study, we aimed to determine CC in non- hypertensive OSAS patients comparing with the control group and determine that CC is affected by the severity of OSAS. Material and Methods: Ninety-three patients with complaints of snoring who were diagnosed as obstructive sleep apnea syndrome with polysomnography were examined in the study between March 2009-November 2010. Renal function tests were performed in these patients and creatinine clearance was calculated. Results: According to the OSAS severity, 30 patients were in the mild, 32 in moderate and 31 in severe OSAS group.There were no statistically significant differences in the demograpic data, systolic and diastolic blood pressure and CC between OSAS and control groups There was no corelation between severity of disease and CC. Conclusion: Due to the pathophysiologic features of OSAS, chronic kidney disease can develop in these patients, although hypertension has not yet developed. Therefore it must be considered that, hypertension may develop in patients with OSAS; blood pressure monitoring, evaluation and monitoring of renal function should not be neglected. © 2012 by Erciyes University School of Medicine.
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    Evaluation of subclinical left ventricular systolic dysfunction in patients with obstructive sleep apnea by automated function imaging method; an observational study [Obstrüktif uyku apneli hastalarda subklinik sol ventrikül sistolik disfonksiyonunun otomatik fonksiyonel görüntüleme yöntemiyle degerlendirilmesi: Gözlemsel bir çali{dotless}şma]
    (2012) Altekin Dr. R.E.; Yanikoglu A.; Karakaş M.S.; Öze D.; Yildirim A.B.; Kabukçu M.
    Objective: We aimed to evaluate the subclinical left ventricular (LV) systolic dysfunction with the automated function imaging method (AFI) based on speckle tracking echocardiography (STE) in obstructive sleep apnea patients (OSA) with normal left ventricular ejection fraction (LVEF) and without any confounding disease that can cause myocardial dysfunction. Methods: Twenty-one healthy individuals and 58 OSA patients were included in this observational cross-sectional study. According to the severity of disease, OSA patients were examined in three groups; mild, moderate and severe OSA. Apical 2-, 3- and 4- chamber images were obtained for AFI evaluation. The global systolic longitudinal strain (GL S) values were determined for each view, and averages of these were used in comparison of the patient groups. One-way ANOVA, Kruskal-Wallis, Pearson correlation tests and linear regression analysis were used for statistical analysis. Results: The GL S values of the OSA patients were lower than of the healthy individuals and these values were decreased along with the OSA severity (Healthy:-25.58±-2.16%, Mild:-23.93±-3.96%, Moderate:-21.27±-2.60%, Severe:-16.94±-2.66%, respectively). The difference was significant between moderate OSA patients and healthy individuals, and significant between severe OSA patients and all other groups (p<0.03). The apnea-hypopnea index was found to be correlated with the GL S (ß=-0.659, 95% CI: 0.09-0.17, p<0.001). Conclusion: Longitudinal LV mechanics in OSA patients with normal LVEF are deteriorated in the subclinical stage being associated with the severity of disease. AFI can be used as an effective and safe method in the determination of subclinical myocardial dysfunction in OSA patients, because it is semi-automated and easy to use with a short analysis time. © Copyright 2012 by AVES Yayi{dotless}nci{dotless}li{dotless}k Ltd.
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    Relation between mean platelet volume and subclinical atherosclerosis in patients with metabolic syndrome [Metabolik sendromlu hastalarda ortalama trombosit hacminin subklinik ateroskleroz ile ilişkisi]
    (Turkish Anaesthesiology and Intensive Care Society, 2014) Gülcan A.R.; Karakaş M.S.; Akdemir B.; Uçar M.; Altekin R.E.; Yilmaz H.
    Objectives: Metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. There is evidence of platelet activation in MetS. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. Therefore, we investigated the possible association between subclinical atherosclerosis, as evaluated by carotid intima-media thickness (CIMT) measurement and MPV, in MetS patients. Study design: Seventy-four patients with MetS were enrolled in the study. Patients were divided into two groups according to CIMT measurement: 35 patients with CIMT ?1.0 mm were in Group 1 and 39 patients with CIMT <1.0 mm were in Group 2. MPV was measured using an automated blood cell counter. Results: The MPV level was significantly higher in patients with CIMT ?1.0 mm than in patients with CIMT <1.0 mm (8.2±0.7 vs. 7.8±0.6 fl; p=0.01). In our study, we observed that platelet count was lower in KIMK ?1.0 mm group and this finding was also found to be statistically significant. Conclusion: The risk of atherosclerosis could be shown by following the MPV values in MetS patients. Therefore, our results suggest that MPV is an important marker for early detection of atherosclerotic risk in patients with MetS. © 2014 Türk Kardiyoloji Dernegi.
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    The effect of nebivolol on P wave duration and dispersion in patients with Behçet's disease; a prospective single-arm controlled study [Behçet hastali{dotless}gi{dotless}nda nebivololün P dalga süresi ve P dalga dispersiyonuna etkisi; prospektif, tek grup kontrollü çali{dotless}şma]
    (AVES Ibrahim Kara, 2013) Akkaya H.; Karakaş M.S.; Şahin Ö.; Borlu M.; Oguzhan A.
    Objective: Behçet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in BD. P wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. PD has been reported to be longer in patients with BD. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the effects of nebivolol on P wave duration and dispersion in patients with BD. Methods: This study was designed as prospective single-arm controlled study. We prospectively studied 35 Behçet's patients who were diagnosed according to the International Study Group criteria. Patients received 5 mg nebivolol per day for 3 months. The patients were evaluated with 12-leads electrocardiography at baseline and after for 3-month therapy. The difference between maximum and minimum P wave durations was defined as PD. The paired samples t test, Wilcoxon test were used for statistical analysis. Results: A significant decrease was observed in PD after therapy period (62.85±21.62 vs. 44.28±18.03 msec, p=0.001). No adverse effects were observed in treatment period. Conclusion: BD is associated with prolonged P wave duration and dispersion. We have shown for the first time that nebivolol causes a significant decrease in maximum P wave duration and PD in patients with BD. However, further comprehensive studies are needed to determine the long-term effects of nebivolol. © 2013 by AVES Yayi{dotless}nci{dotless}li{dotless}k Ltd.