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Öğe Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications(C M B Assoc, 2020) Salehi, Bahare; Selamoglu, Zeliha; Sevindik, Mustafa; Fahmy, Nouran M.; Al-Sayed, Eman; El-Shazly, Mohamed; Csupor-Loffler, BoglarkaThe genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. In a number of preclinical studies, Achillea plants and their essential oils have demonstrated promising antibacterial properties against a number of human and plant pathogens. Besides, the plants have displayed strong antioxidative and potent anti-proliferative and anticancer proper-ties in various cellular and animal models. Achillea plants have widely been used as food preservative in food industry. Clinical studies have indicated its potential against multiple sclerosis (MS), irritable bowel syndrome (IBS), ulcerative colitis, episiotomy wound, primary dysmenorrhea, oral mucositis etc. The present work focuses to provide a brief overview on folk knowledge, phytochemistry, biological activity and applications of Achillea plants. There is a close relationship between the traditional ethnobotanical usage and pharmacological and clinical data from different Achillea spp. The application of Achillea plants and their extracts seems to be a promising alternative for antimicrobial and antioxidant purposes in food, pharmaceutical and cosmetic industries.Öğe Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey(Hindawi Ltd, 2020) Sevindik, Mustafa; Akgul, Hasan; Selamoglu, Zeliha; Braidy, NadyInfundibulicybe geotropa (Bull.) Harmaja is an edible mushroom found in Bolu province in northwestern Turkey. The chemical composition and bioactivity of these mushrooms has not been previously investigated. We examined the phenolic composition, elemental content, and antioxidant and antigenotoxic effects of methanol extracts of fruiting bodies. The phenolic compounds in the fungal samples were determined using high-performance liquid chromatography (HPLC), and element content was determined using atomic absorption spectrophotometry. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined using the commercially available Rel assay kit. The antigenotoxic effects of the extract were determined using the MTT assay to assess cell viability and the alkaline single-cell gel electrophoresis assay (Comet assay). The total phenolic content (ppm) of I. geotropa was found to be catechin (361 +/- 2.31), clorogenic acid (553.54 +/- 5.06), and coumaric acid (9.93 +/- 0.25). The TAS, TOS, and OSI of the extract were 1.854 +/- 0.051 mmol/L, 30.385 +/- 0.399 mu mol/L, and 1.639 +/- 0.067, respectively. The elemental levels were within normal range. In HT22 mouse hippocampal neuronal cells, the extract (100 and 200 mu g/ml) showed no genotoxic potential and ameliorated hydrogen peroxide- (H2O2-) induced oxidative DNA damage. I. geotropa may be considered a good nutrient due to its phenolic constituents and antioxidant potential.Öğe ANTIOXIDANT ANTIMICROBIAL OXIDANT AND ELEMENTS CONTENTS OF XYLARIA POLYMORPHA AND X. HYPDXYLON (XYLARIACEAE)(Parlar Scientific Publications (P S P), 2021) Saridogan, Beste Gizem Ozbey; Islek, Cemil; Baba, Hayri; Akata, Ilgaz; Sevindik, MustafaIn the current study, antioxidant, oxidant, and antimicrobial potentials of Xylaria polymorpha (Pers.) Grey. and X hypoxylon (L.) Grey. were determined. Also, the levels of elements accumulated by these fungi were measured. The samples were extracted with ethanol in soxhlet apparatus. Antioxidant and oxidant potentials were determined using Rel Assay kits. Antimicrobial activities were tested using the agar dilution method. Element contents were determined using atomic absorption spectrophotometer. As a result of the studies, TAS, TOS, and OSI values of X hypoxylon were determined as 3.794 +/- 0.188, 8.609 +/- 0.171, and 0.228 +/- 0.015, respectively. TAS, TOS, and OSI values of X. polymorpha were determined as 5.390 +/- 0.176, 14.738 +/- 0.126, and 0.274 +/- 0.008, respectively. Besides, it was observed that the antimicrobial activities of the extracts of mushrooms were effective at 50-400 mu g/mL concentrations. Element contents were determined to be at normal levels compared to literature data. As a result, it was determined that X. polymorpha and X. hypoxylon have antioxidant and antimicrobial potentials.Öğe Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P.Kumm.(Biointerface Research Applied Chemistry, 2020) Selamoglu, Zeliha; Sevindik, Mustafa; Bal, Celal; Ozaltun, Betul; Sen, Ismail; Pasdaran, ArdalanTricholoma is one of the famous genera of Basidiomycota division. Although some species of this genus have been used as culinary mushrooms, very negligible investigations have been conducted on Tricholoma genus phenolic contents and their biological activities. In the present study, the antioxidant, antimicrobial, and DNA protection properties of total phenolic contents of Tricholoma virgatum (Fr.) P. Kumm. (54% methanolic extract) were assessed. T. virgatum phenolic content was determined by an analytic high-performance liquid chromatography (HPLC) method based on compression with standard phenolic compounds including gallic acid, catechin, chlorogenic acid, epicatechin, and coumaric acid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were determined using Rel Assay kits. For DNA protective potential assay, pBR322 supercoiled DNA method was used. The antimicrobial activity assay was done based on the agar dilution method on six different microorganisms include Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Candida tropicalis. The total phenolic contents of this mushroom lied within range of 2.02-56.85 ppm based on coumaric acid and chlorogenic acid as standards. TAS, TOS, and OSI values were determined as 3.754 +/- 0.088 mmol/L, 8.362 +/- 0.085 mu mol/L, and 0.223 +/- 0.007, respectively. T. virgatum methanol extract could exhibit a protective effect on DNA against the hydroxyl radical at 100 mu g/mL concentration. Although T. virgatum is not recommended as an edible mushroom, according to our results, this mushroom could be considered as valuable source for phenolic compounds with significant antioxidant/antimicrobial effects.Öğe Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro(Taylor & Francis Ltd, 2021) Sevindik, Mustafa; Akgul, Hasan; Selamoglu, Zeliha; Braidy, NadyOctaviania asterosperma (hypogeous Basidiomycota) We investigated the phenolic composition, and antioxidant, antimicrobial and antigenotoxic effects of methanol extracts of fruiting bodies from Octaviania asterosperma. The total phenolic content (ppm) of O. asterosperma was found to be catechin (54.73 +/- 4.68), epicatechin (123.90 +/- 8.52), caffeic acid (4.23 +/- 0.97), p-hydroxybenzoic acid (37.72 +/- 3.84), cinnamic acid (58.07 +/- 5.40), gallic acid (56.64 +/- 6.39), clorogenic acid (80.76 +/- 4.92) and coumaric acid (2.45 +/- 0.15). The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were 3.410 +/- 0.099 mmol/L, 7.548 +/- 0.147 mu mol/L and 0.221 +/- 0.005 respectively. O. asterosperma showed some promising antimicrobial activity. The extract showed no genotoxic potential and attenuated hydrogen peroxide (H2O2)-induced oxidative DNA damage in neurons. Pre-treatment with O. asterosperma maintained mitochondrial function, reduced expression levels of cleaved-caspase-3 and apoptosis-inducing factor (AIF) when HT22 cells were exposed to pathophysiological concentrations of GLU (25 mM) and modulated protein kinase B (Akt), the mammalian target of rapamycin (mTOR), and the phosphotase and tensin homolog on chromosome ten (PTEN). O. asterosperma is an important food for the treatment or management of neurodegenerative disorders due to its phenolic content and potent antioxidant and anti-excitotoxic effects.Öğe BIOLOGICAL ACTIVITIES AND HEAVY METAL CONTENTS OF SOME PHOLIOTA SPECIES(Parlar Scientific Publications (P S P), 2021) Islek, Cemil; Saridogan, Beste Gizem Ozbey; Sevindik, Mustafa; Akata, IlgazIn this study, antioxidant, oxidant, and antimicrobial activities of some Pholiota species (Pholiota adiposa (Batsch) P. Kumm., P lubrica (Pers.) Singer and P. squarrosa (Vahl) P. Kumm.) were determined. Also, the Fe, Cu, Zn, Pb, Cr, Mn, Ni, and Cd levels accumulated in the fruiting bodies of these species were measured. Ethanol extracts of the mushroom specimens have been prepared. The antioxidant and oxidant status of the extracts were determined using Rel Assay kits. Also, the antibacterial and antifungal activities of the extracts were determined using the agar dilution method. Heavy metal levels of the samples were determined using atomic absorption spectrophotometer. As a result of the studies, the highest TAS value was determined in P squarrosa. The highest TOS value was determined in P lubrica. Generally, antibacterial and antifungal activities were observed in P lubrica, Generally, element levels fell within the literature ranges. Besides, it is thought that all three types of species can be used as an indicator due to their high Ni contents. As a result, it was determined that P adiposa, P lubrica and P squarrosa can be used as antioxidant and antimicrobial natural agents.Öğe Biological Activities of Wild Poisonous Mushroom Entoloma sinuatum (Bull.) P. Kumm (Boletales)(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2022) Bal, Celal; Baba, Hayri; Akata, Ilgaz; Sevindik, Mustafa; Selamoglu, Zeliha; Akgul, HasanIn many studies conducted in recent years, it has been found that the beneficial natural ingredients found in mushrooms are very important in curing various diseases and eliminating disease factors. It has been reported that fungi that spread in different countries have biological activities. In this study, antioxidant level (TAS). oxidant level (TOS), and antibacterial and antifungalactivity of Entoloma sinuatum (Bull.) P. Kumm were determined. Ethanol extract of the mushroom was extracted in a Soxhlet apparatus. Antioxidant and oxidant levels were determined using Rel Assay TAS and TOS kits. Also. antimicrobial activity was tested against bacteria l and fungal strains using the agar dilution method. As a result of the studies. the TAS value of the mushroom was determined 2.64 +/- 0.15. the TOS value vas 6.58 +/- 0.23, and the OSI (Oxidative stress index) value was 0.25 +/- 0.02. In addition, it was determined that the ethanol extract of the mushroom was effective against bacteria at 200 and 400 mu g/mL, and against fungi at 50 mu g/mL concentrations. As a result, it was determined that E. sinuatum is a natural antioxidant and antimicrobial agent.Öğe Desmodium adscendens (Sw.) DC.: A magnificent plant with biological and pharmacological properties(Wiley, 2022) Manzione, Maria Giulia; Herrera-Bravo, Jesus; Sharifi-Rad, Javad; Kregiel, Dorota; Sevindik, Mustafa; Sevindik, Emre; Salamoglu, ZelihaDesmodium adscendens (Sw.) DC. is a plant of the Fabaceae family especially rich in flavonoids but also in alkaloids, terpenoids, steroids, phenols, phenylpropanoids, glycosides, and volatiles. This herb has been traditionally used in numerous countries all over the world for its pharmacological and biological properties (i.e., it has been used for the treatment of diarrheas, fever, epilepsy, asthma, leishmaniasis, gastroduodenal ulcer, diabetes, hepatic diseases, etc.). Given the wide uses of D. adscendens, this review summarizes all recent data on D. adscendens evaluating its phytochemistry as well as its ethno-traditional and pharmacological properties. In addition, an association between the phytocompounds of this plant and its potential mechanism of action in cell and animal models has been investigated, focusing with a special emphasis on human experiments.Öğe DETERMINATION OF ANTIOXIDANT, ANTIMICROBIAL, DNA PROTECTIVE ACTIVITY AND HEAVY METALS CONTENT OF LAETIPORUS SULPHUREUS(Parlar Scientific Publications (P S P), 2018) Sevindik, Mustafa; Akgul, Hasan; Dogan, Muhittin; Akata, Ilgaz; Selamoglu, ZelihaSince ancient times, people consumed mushrooms as nutrients, especially during the rainy season. The present study aimed to determine the therapeutic potential of an edible mushroom, Laetiporus sulphureus (Bull.) Murrill. Thus, its antioxidant activity was determined by DPPH method and antimicrobial activity was determined with modified agar dilution method. TAS (total antioxidant status), TOS (total oxidant status) and OSI (oxidative stress index) values were determined using Rel Assay kits. PBR 322 supercoiled DNA was used to identify the DNA protective activity. Heavy metal content was determined with atomic absorption spectrophotometry using the wet decomposition method. In conclusion, it was determined that L. sulphureus demonstrated high biological activity and it was considered that the mushroom can be used as a natural resource in alternative medicine.Öğe DETERMINATION OF THERAPEUTIC POTENTIAL OF MENTHA LONGIFOLIA SSP LONGIFOLIA(Parlar Scientific Publications (P S P), 2017) Sevindik, Mustafa; Akgul, Hasan; Pehlivan, Mustafa; Selamoglu, ZelihaThe present study aimed to determine antioxidant, antimicrobial activities and oxidative stress properties of the ethanol extracts of Mentha longifolia L. Hudson subsp. longifolia. Antioxidant activity was determined with the DPPH method. Antimicrobial activity was tested on six different microorganisms (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Candida tropicalis) using modified agar dilution method. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were determined using Rel Assay kits. It was observed that DPPH and antimicrobial potentials of plant samples varied based on the locations they were collected. As a result, it was considered that plant samples could be used as natural antioxidant and antimicrobial resources, but suitable regions for OSI values should be selected.Öğe Determination of therapeutic potential of mentha longifolia ssp. Longifolia(Parlar Scientific Publications, 2017) Sevindik, Mustafa; Akgul, Hasan; Pehlivan, Mustafa; Selamoglu, ZelihaThe present study aimed to determine antioxidant, antimicrobial activities and oxidative stress properties of the ethanol extracts of Mentha longifolia L. Hudson subsp. longifolia. Antioxidant activity was determined with the DPPH method. Antimicrobial activity was tested on six different microorganisms (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Candida tropicalis) using modified agar dilution method. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were determined using Rel Assay kits. It was observed that DPPH and antimicrobial potentials of plant samples varied based on the locations they were collected. As a result, it was considered that plant samples could be used as natural antioxidant and antimicrobial resources, but suitable regions for OSI values should be selected. © by PSP.Öğe Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World(Mdpi, 2021) Rehman, Muhammad Fayyaz ur; Akhter, Shahzaib; Batool, Aima Iram; Selamoglu, Zeliha; Sevindik, Mustafa; Eman, Rida; Mustaqeem, MuhammadThe SARS CoV-2 pandemic has affected millions of people around the globe. Despite many efforts to find some effective medicines against SARS CoV-2, no established therapeutics are available yet. The use of phytochemicals as antiviral agents provides hope against the proliferation of SARS-CoV-2. Several natural compounds were analyzed by virtual screening against six SARS CoV-2 protein targets using molecular docking simulations in the present study. More than a hundred plant-derived secondary metabolites have been docked, including alkaloids, flavonoids, coumarins, and steroids. SARS CoV-2 protein targets include Main protease (M-Pro), Papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), Spike glycoprotein (S), Helicase (Nsp13), and E-Channel protein. Phytochemicals were evaluated by molecular docking, and MD simulations were performed using the YASARA structure using a modified genetic algorithm and AMBER03 force field. Binding energies and dissociation constants allowed the identification of potentially active compounds. Ligand-protein interactions provide an insight into the mechanism and potential of identified compounds. Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for M-Pro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp. The use of identified phytochemicals may help to speed up the drug development and provide natural protection against SARS-CoV-2.Öğe Evaluation of the effects on atherosclerosis and antioxidant and antimicrobial activities of Agaricus xanthodermus poisonous mushroom(2020) Özaltun, Betül; Sevindik, MustafaObjectives: The aim of this study was to determine the total antioxidant capacity, total oxidant capacity,oxidative stress index and antimicrobial activity of a poisonous mushroom Agaricus xanthodermus. The effectsof mushrooms on atherosclerosis are due to their antioxidant effects.Methods: Mushroom samples collected from study field were extracted with methanol (MeOH) anddichloromethane (DCM) using soxhlet apparatus. Total antioxidant status (TAS), total oxidant status (TOS)and oxidative stress index (OSI) were measured using Rel Assay trade kits. Antimicrobial activities were testedon 9 microorganisms (Staphylococcus aureus, S. aureus MRSA, Enterococcus faecalis, Escherichia coli,Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans, C.krusei and C. glabrata) using themodified agar dilution method.Results: In this study A. xanthodermus has shown high antioxidant and antimicrobial activities. In addition,the highest activities of MeOH and DCM extracts of the mushrooms were demonstrated against E. coli, P.aeruginosa, and A. baumannii.Conclusions: In conclusion, A. xanthodermus is considered to be a poisonous mushroom and can be used as apharmacological natural agent due to its high antioxidant and antimicrobial activities.Öğe GENE EXPRESSION LEVELS IN BRONCHIAL ASTHMA PATIENTS OF DUHOK POPULATION IN IRAQ(Parlar Scientific Publications (P S P), 2021) Issa, Hamdia Yousif; Al-Habib, Omar A. M.; Dastan, Sevgi Durna; Ramadhan, Ali A.; Sevindik, Mustafa; Selamoglu, ZelihaBronchitis, asthma, allergy and bronchial asthma diseases are very common in these years. These diseases, which have increased with the age in the past, are nowadays frequently seen from very early ages and even from infancy. In addition. the frequency of these diseases varies according to different populations. It is suggested that environmental factors, genotypic structure of individuals have special effects or additive effects in these diseases which are also associated with the immune system not working effectively. The aim of our study is to determine the expression levels in some genes that are suggested to be related to these diseases in blood samples between the patient and control groups. In this study, gene expression values performed with the RT-PCR analysis are compared between brochititis-asthma patient group and control group by using 16 gene region. According to RTPCR gene expression analysis, individuals with bronchial-asthma have had remarkable increases or decreases in some gene regions. Some of these changes were found statistically significant.Öğe Lycopene: Food Sources, Biological Activities, and Human Health Benefits(Hindawi Ltd, 2021) Khan, Usman Mir; Sevindik, Mustafa; Zarrabi, Ali; Nami, Mohammad; Ozdemir, Betul; Kaplan, Dilara Nur; Selamoglu, ZelihaAs an antioxidant, lycopene has acquired importance as it prevents autoxidation of fats and related products. Tomatoes are an important agricultural product that is a great source of lycopene. It contains many vitamins and minerals, fiber, and carbohydrates and is associated with various positive effects on health. The antioxidant potential of tomatoes is substantially explained with lycopene compounds. Diet is a major risk factor for heart diseases which is shown as the most important cause of death in the world. It has been observed that the lycopene taken in the diet has positive effects in many stages of atherosclerosis. The serum lipid levels, endothelial dysfunction, inflammation, blood pressure, and antioxidative potential are mainly affected by lycopene. These natural antioxidants, which can also enhance the nutritional value of foods, may lead to new ways if used in food preservation. In this review study, the antioxidant potential and cardiovascular protection mechanism of lycopene are discussed.Öğe Oxidant/antioxidant potentials and heavy metal levels of Pisolithus arhizus and its effects on cardiovascular diseases(National Institute of Science Communication and Information Resources, 2021) Sevindik, Mustafa; Ajaz, Mahvish; Özdemir, Betül; Akata, Ilgaz; Selamoğlu, ZelihaPisolithus arhizus (Scop) Rauschert is a cosmopolitan mushroom in warm temperate regions of the world and forms ectomycorrhizas associations with a wide range of tree species (both angiosperms and gymnosperms). P. arhizus samples were collected from a pine forest in Antalya province (Turkey). Powdered mushroom samples were extracted with ethanol (EtOH) using a Soxhlet apparatus at 50 °C, then concentrated under pressure at 40 °C in a rotary evaporator, and stored at 4 °C in airtight containers. Rel Assay Kits were used to determine the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) of mushroom extracts. The elemental contents of the mushrooms were then determined using the atomic absorption spectrophotometer. It was determined that the heavy metal content in P. arhizus were found to be generally at optimal levels and the TOS value of mushroom was exceptional. Heavy metals are toxic, they may have chronic degenerative changes on organs. Vascular effects of heavy metals may contribute to a variety of pathologic conditions. Heavy metals resulting in pathophysiological changes causes atherogenic events like increased oxidative stress, inflammatory response, and coagulation activity. It has been determined that P. arhizus may be an important source of antioxidants. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.Öğe OXIDATIVE STRESS INDEX AND ANTIOXIDANT CAPACITY OF LEPISTA NUDA COLLECTED FROM GAZIANTEP/TURKEY(Yildiz Technical Univ, 2019) Bal, Celal; Sevindik, Mustafa; Akgul, Hasan; Selamoglu, ZelihaThe objective of the present study was to determine antioxidant capacity and oxidative stress index of Lepista nuda (Bull.) Cooke mushrooms collected in Sahinbey (Gaziantep/Turkey) using novel research kits that could conduct high sensitive and reliable measurements with in vitro analysis methods. Its antioxidant activity was determined by DPPH method and TAS (total antioxidant status), TOS (total oxidant status) and OSI (oxidative stress index) values were determined using Rel Assay kits. Study findings determined that the TAS value was 3.102 mmol/L, the TOS value was 36.920 mu mol/L and the OSI value was 1.190 for the mushroom. It was observed that the radical scavenging activity of DPPH increased in higher concentrations. It was concluded that L. nuda samples collected in regions with low TOS values could be used as better antioxidant sources.Öğe Phenolic composition, total antioxidant, antiradical and antimicrobial potential of endemic Glaucium Alakirensis(Yildiz Technical Univ, 2024) Ozcandir, Aysen; Mohammed, Falah Saleh; Sevindik, Mustafa; Aykurt, Candan; Selamoglu, Zeliha; Akgul, HasanPlants have been used by many communities for different purposes such as food, shelter, medicine. The present study aimed to determine phenolic content and biological potential of Glaucium alakirensis Aykurt, K. Yildiz & A. 0zcandir, which is endemic to Antalya (Turkey). Phenolic composition of the plant was analyzed with HPLC device, while antiradical activity was determined by DPPH method. Antimicrobial tests were conducted with agar dilution method against standard bacteria and fungus strains. Total antioxidant and oxidant status were determined using Rel Assay kits. As a result of HPLC analysis, the presence of catechin, chlorogenic acid, hydroxybenzoic acid, quercetin and gallic acid was determined. Plant extracts were effective against microorganisms at concentrations of 50-200 mu g/mL. It was determined that the plant has high antiradical activity. It is also thought to be used as a natural source for relieving oxidative stress.Öğe PHENOLIC COMPOUND AND ANTIOXIDANT POTENTIAL OF(Univ Agronomic Sciences & Veterinary Medicine Bucharest - Usamv, 2023) Ahmad, Zaheer; Ozdemir, Betul; Sevindik, Mustafa; Eraslan, Emre Cem; Selamoglu, Zeliha; Bal, CelalMushrooms have been used for both culinary and medicinal reasons for a very long time. Mushrooms are useful as both a food and a medication due to their high nutritional, protein, vitamin, and phenolic content. The current research aims to determine the antioxidant activity and phenolic content of Hebeloma sinapizans. Multiple epidemiological research looked at the possible link between polyphenol consumption and cardiovascular illness. Antioxidant, antiplatelet, antiinflammatory, antilipidemic, and antihypertensive are the categories used to classify the actions of phenolic substances. HPLC was used to isolate the phenolic compounds (HPLC). Measurements of oxidative stress, total oxidant levels, and total antioxidant levels were all calculated with the use of Rel Assay kits. The mushroom's TAS, TOS, and OSI values were measured, and its gallic acid, chlorogenic acid, and cinnamic acid concentrations were identified. Due to its high levels of phenolic compounds, H. synapizans is thought to be a source of phenolic compounds. High TAS and TOS values and low OSI values indicate that the mushroom has antioxidant potential. As a result, it has been seen that H. synapizans can be a good source of antioxidants.Öğe PHENOLIC COMPOUND AND ANTIOXIDANT POTENTIAL OF Hebeloma sinapizans MUSHROOM(University of Agronomic Sciences and Veterinary Medicine of Bucharest, 2023) Ahmad, Zaheer; Özdemir, Betül; Sevindik, Mustafa; Eraslan, Emre Cem; Selamoglu, Zeliha; Bal, CelalMushrooms have been used for both culinary and medicinal reasons for a very long time. Mushrooms are useful as both a food and a medication due to their high nutritional, protein, vitamin, and phenolic content. The current research aims to determine the antioxidant activity and phenolic content of Hebeloma sinapizans. Multiple epidemiological research looked at the possible link between polyphenol consumption and cardiovascular illness. Antioxidant, antiplatelet, antiinflammatory, antilipidemic, and antihypertensive are the categories used to classify the actions of phenolic substances. HPLC was used to isolate the phenolic compounds (HPLC). Measurements of oxidative stress, total oxidant levels, and total antioxidant levels were all calculated with the use of Rel Assay kits. The mushroom's TAS, TOS, and OSI values were measured, and its gallic acid, chlorogenic acid, and cinnamic acid concentrations were identified. Due to its high levels of phenolic compounds, H. synapizans is thought to be a source of phenolic compounds. High TAS and TOS values and low OSI values indicate that the mushroom has antioxidant potential. As a result, it has been seen that H. synapizans can be a good source of antioxidants. © 2023 The Author(s).
