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Öğe An Optical Coherence Tomography Study that Supports the Neurovascular Basis of Schizophrenia Disease(Aves, 2022) Kurt, Aydin; Zor, Kursad Ramazan; Kucuk, Erkut; Yildirim, Gamze; Ersan, Etem ErdalObjectives: Spectral domain optical coherence tomography (SD-OCT) is a non-penetrating, quick, and practical device which enables measurement of the chorioretinal layers. In this study, our purpose was to investigate the retinal nerve fiber layer (RNFL) and choroidal thickness in schizophrenia patients, using SD-OCT, and compare the -findings with those of the control group. Methods: For the study, 44 patients with a diagnosis of schizophrenia, and 41 age- and gender-matched healthy controls were enrolled. Both eyes of each participant were-evaluated. RNFL was measured and analyzed automatically with optical coherence tomography. Scans for choroidal thickness were obtained with the enhanced depth imaging mode of the SD-OCT device and measured manually. Results: The average age of schizophrenia patients was 47.82, and it was 45.5 for the control group. The mean illness duration of the patients was 24.79 years. According to the results of this study, all choroidal measures (nasal, subfoveal, and temporal) of both eyes, and the RNFL thickness of schizophrenia patients, were significantly thinner than that of healthy controls. The chorioretinal measures of both eyes were similar. The results showed that a weak negative correlation was present between illness duration and choroidal diameter. Conclusion: In addition to demonstrating the thinning of RNFL in schizophrenia patients, as frequently reported in the literature, the results of this study show, for the first time, that choroidal thickness is considerably decreased in schizophrenia patients compared to the healthy controls, using SD-OCT. Keeping in mind that the choroid is a vascular layer, these results support the neurovascular hypothesis of schizophrenia.Öğe EFFECT EFFECT OF FLY ASH CONTRIBUTION TO THE PHYSICAL AND MECHANICAL PROPERTIES OF CEMENTED PUMICE-BASED LIGHTWEIGHT WALL MATERIAL(Parlar Scientific Publications (P S P), 2017) Dogan-Saglamtimur, Neslihan; Bilgil, Ahmet; Yildirim, Gamze; Bay, Tugce; Doguc, Unal; Erkekli, KubraIn this study, using CEM I and CEM II type cements in different mixing ratios, pumice-based lightweight wall material with the contribution of fly ash (FA) was produced so as to evaluate the likely use of this waste material in the construction sector. Physical and mechanical properties were determined in the samples. This study consists of two stages. In the first stage, pumice in 0-4 mm size was used as coarse aggregate. The average axial compressive strength (ACS) values of samples obtained by using only pumice were 9.2 and 11.7 MPa for Bims Concrete 40 (BC40) and BC80 in CEM I, 5.05 and 10.6 MPa for BC40 and BC80 in CEM II, respectively. In the second stage, FAs were added (25, 50, 75 and 100% in weight) as fine aggregates. The ACS values of samples obtained by using FA additive in different ratios ranged from 4.15 to 5.2 MPa for BC40 in CEM I, 3.0 to 3.45 MPa for BC40 in CEM II, respectively, on the other hand, they ranged from 7.4 to 8.7 MPa for BC80 in CEM I, and 4.9 to 6.8 MPa for BC80 in CEM II, respectively. Turkish and European (TS-EN) standards were used to do experiments and interpret the results.Öğe Evaluation of the Effect of Proptosis on Choroidal Thickness in Graves' Ophthalmopathy(Turkish Ophthalmological Soc, 2020) Yildirim, Gamze; Sahli, Esra; Alp, Mehmet NumanObjectives: To evaluate the effect of proptosis on choroidal thickness in patients with Graves' ophthalmopathy. Materials and Methods: Twenty-five eyes of 25 Graves' patients with proptosis, 25 eyes of 25 Graves' patients without proptosis, and 25 eyes of 25 healthy individuals were included in this prospective study. The subfoveal choroidal thickness and choroidal thicknesses at 6 points from the fovea at 500 mu m intervals were measured by Cirrus HD-OCT. All measurements were compared among the proptosis, non-proptosis, and control groups and the active, inactive, and control groups. Results: The mean subfoveal choroidal thickness in the proptosis group was 289.7 +/- 68.5 mu m, 322.5 +/- 55.8 mu m in the non-proptosis group, and 316.1 +/- 63.0 mu m in the control group. The mean nasal choroidal thickness was 260.5 +/- 63.5 mu m in the proptosis group, 293.9 +/- 57.9 mu m in the non-proptosis group, and 279.5 +/- 63.1 mu m in the control group. The mean temporal choroidal thickness was 261.8 +/- 60.9 mu m in the proptosis group, 289.0 +/- 51.8 mu m in the non-proptosis group, and 287.8 +/- 56.2 mu m in the control group. Mean choroidal thickness was 264.7 +/- 58.5 mu m in the proptosis group, 296.2 +/- 47.5 mu m in the non-proptosis group, and 288.3 +/- 55.1 mu m in the control group. There were no statistically significant differences among the groups with respect to choroidal thickness measurements (p>0.05). Conclusion: No significant difference in choroidal thickness was detected between Graves' patients with and without proptosis and the controls. There was no effect of clinical activation on choroidal thickness.Öğe Relationship between echocardiography and arterial stiffness parameters and chorodial thickness in healthy subjects(Edizioni Minerva Medica, 2022) Akkaya, Hasan; Zor, Kursad R.; Gunturk, Ertugrul E.; Kucuk, Erkut; Yildirim, GamzeABSTR A C T BACKGROUND: Choroid is one of the most vascularized tissues of the body. Enhanced depth imaging optical coher-ence tomography (EDI-OCT) is the diagnostic method for choroid imaging. An increase in arterial stiffness, one of the important determinants of vascular aging, is a prognostic predictor of cardiovascular mortality. Carotid-femoral pulse wave velocity (CFPWV) is the gold standard method for the detection of arterial stiffness and has a high predictive value for undesirable cardiovascular events. The aim of our study was to investigate whether there is a relationship between choroidal thickness and echocardiographic findings, CFPWV, arterial stiffness, aortic distensibility and other basic pa-rameters in healthy middle-aged subjects. METHODS: The study included 80 healthy individuals aged 30-60 years. Firstly, echocardiographic and arterial stiffness levels of volunteers were evaluated, and choroidal thickness was determined by EDI-OCT. The relationship between choroidal thickness and other parameters was evaluated by Pearson correlation test. RESULTS: A total of 80 healthy volunteers (35 females, 43%) were included in the study. The mean age was 42.40-17.68 years (range, 31-60 years). It was found that there were a negative correlation between choroid and age (r=-0.80, P<0.01), left ventricular deceleration time (r=-0.72, P<0.01), isovolumic relaxation time (r=-0.76, P<0.01), ee (r =-0.68, P<0.01), annular late diastolic velocity (r=-0.25, P<0.05), CFPWV (r=-0.70, P<0.01) and aortic stiffness (r=-0.76, P<0.01). There was a significant positive correlation between choroid and aortic distensibility (r=0.81, P<0.01). There was no difference between the genders in terms of choroidal thickness (t[77]=0.47, P>0.05). CONCLUSIONS: Correlation between advanced age, left ventricular diastolic dysfunction, increased arterial stiffness parameters, decreased aortic distensibility and choroidal thinning were observed.Öğe Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients(Sage Publications Ltd, 2020) Zor, Ramazan Kursad; Ersan, Serpil; Kucuk, Erkut; Yildirim, Gamze; Sari, IsmailPurpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants (n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group (p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group (p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.Öğe Vogt Koyanagi Harada syndrome in a 15-year-old girl, steroids side effects and recurrences(Turkish J Pediatrics, 2021) Yildirim, Gamze; Cavdarli, Cemal; Ozdemir, Emine Yildiz; Alp, Mehmet NumanBackground. Vogt-Koyanagi-Harada Syndrome is rare in childhood and is usually seen between the 2nd and 5th decades. We present a 15-year-old girl with findings of incomplete Vogt-Koyanagi-Harada Syndrome. Case. In the first visit, anterior chamber inflammation, vitritis, serous retinal detachment and papillitis were observed in her both eyes. She also had neurological symptoms such as a headache. During the systemic treatment period, some of the side effects related to steroids emerged. Additionally, the symptoms and findings of the disease relapsed while the steroid dose was reduced. Conclusion. Early diagnosis and selection of an individualized appropriate treatment provided good clinical and visual results without any serious complications in our case.Öğe X-Linked Retinoschisis in Females in a Consanguineous Family: A Rare Entity(Turkish Ophthalmological Soc, 2020) Onen, Mehmet; Zor, Kursat; Kucuk, Erkut; Yildirim, GamzeX-linked juvenile retinoschisis (XLRS) is a disease considered characteristic for males. In this study we report a consanguineous family in which 3 daughters were diagnosed with XLRS. Typical signs of XLRS were detected in 2 girls, aged 4 and 15. Fundoscopic examination of the father and the oldest daughter (age 17) revealed bilateral atrophic macula and retinal thinning. Although rare and considered characteristic for males, XLRS can be seen in females in Middle-East countries that have a high rate of consanguineous marriage. It can be overlooked by ophthalmologists and these patients may be misdiagnosed.
