Evaluation of Glucagon-like Peptide-1, Adropin, and Desnutrin Levels and Related Factors in Patients with Bipolar Disorder

Basit Öğe Kaydı
dc.authoridKurt, Aydin/0000-0001-7293-1646
dc.contributor.authorErsan, Serpil
dc.contributor.authorKurt, Aydin
dc.date.accessioned2024-11-07T13:31:25Z
dc.date.available2024-11-07T13:31:25Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: It is known that impaired energy metabolism contributes to the neuropathology of bipolar disorder (BD). This study aimed to compare the levels of glucagon-like peptide-1 (GLP-1), adropin, and desnutrin, which have many metabolic functions besides the regulation of energy metabolism, between patients with BD and healthy controls and to investigate the related factors. Methods: In the study group, 73 age- and sex-matched participants were included. Of them, 35 were patients diagnosed with BD and 38 were healthy individuals. In the blood samples, in addition to routine biochemistry lipid parameters, the levels of adropin, desnutrin, and GLP-1 were determined. Results: Adropin, desnutrin, and GLP-1 levels were significantly lower in patients with BD than in healthy controls (P < 0.001). In contrast, body mass index, total cholesterol, triglyceride, and low-density lipoprotein levels were significantly higher in patients with BD than in healthy controls (respectively P < 0.001, P= 0.001, P= 0.002, P= 0.001). It was observed that adropin levels decreased significantly as the duration of the disease increased. Conclusion: The low levels of adropin, desnutrin, and GLP-1 that we determined in patients with BD indicate that these peptides may be important in BD pathophysiology.
dc.identifier.doi10.5455/apd.118046
dc.identifier.endpage6
dc.identifier.issn2757-8038
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85100820271
dc.identifier.scopusqualityN/A
dc.identifier.startpage1
dc.identifier.trdizinid422106
dc.identifier.urihttps://doi.org/10.5455/apd.118046
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/422106
dc.identifier.urihttps://hdl.handle.net/11480/14834
dc.identifier.volume22
dc.identifier.wosWOS:000623093500003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofAlpha Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBipolar disorder
dc.subjectadropin
dc.subjectdesnutrin
dc.subjectglucagon-like peptide-1
dc.titleEvaluation of Glucagon-like Peptide-1, Adropin, and Desnutrin Levels and Related Factors in Patients with Bipolar Disorder
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu