The Condylar Effects of Mesenchymal Stem Cells, Low-Level Laser Therapy and Grape Seed Extract on Functional Mandibular Advancement of the Rat Mandible

Basit Öğe Kaydı
dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.authoridGulec, Aysegul/0000-0001-8838-1546
dc.authoridTuglu, Mehmet Ibrahim/0000-0002-0569-8415
dc.contributor.authorEglenen, Merve Nur
dc.contributor.authorTuglu, Mehmet Ibrahim
dc.contributor.authorAydemir, Isil
dc.contributor.authorGulec, Aysegul
dc.date.accessioned2024-11-07T13:35:13Z
dc.date.available2024-11-07T13:35:13Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Functional treatment of Class II malocclusion is expected to lead to adaptation in the condyle. This study aimed to evaluate the effects of adipose tissue-derived mesenchymal stem cells (ADMSCs), low-level laser therapy (LLLT), and grape-seed extract (GSE) on condylar growth after functional mandibular advancement. Methods: Forty-five rats were randomly divided into 8 groups. Functional appliances were applied to all groups (n=6) except the control group (n=3). One group was treated with appliances only; the other six groups received various combinations of ADMSCs, LLLT, and GSE. Analyses for new osteoblasts and new bone formation, vascular endothelial growth factor, and Type II collagen were performed on condylar tissues, after an experimental period of four weeks. The quantitative data obtained from the results of the experiments were evaluated by H-score and analyzed using One-Way ANOVA by Tukey-Kramer multiple comparisons test (p=0.05). Results: Levels of all investigated parameters increased in all groups (p <= 0.05). The highest increases were achieved by a combined application of functional appliance, ADMSCs, LLLT and GSE (p <= 0.05). Single LLLT administrations or single GSE applications did not create a statistical difference from appliance alone (p>0.05). A positive effect of ADMSCs or LLLT on osteoblast formation, neovascularization, and Type II collagen level was apparent (p <= 0.05), however, neither affected new bone formation (p>0.05). Conclusion: This study shows that ADMSCs with LLLT and GSE applications provide differing levels of new osteoblast and bone formation, new vascular formation, and Type II collagen formation in rat condyles after functional mandibular advancement.
dc.identifier.doi10.4274/TurkJOrthod.2022.2022.92
dc.identifier.endpage86
dc.identifier.issn2148-9505
dc.identifier.issue2
dc.identifier.pmid37345991
dc.identifier.scopus2-s2.0-85167341685
dc.identifier.scopusqualityQ3
dc.identifier.startpage79
dc.identifier.trdizinid1183817
dc.identifier.urihttps://doi.org/10.4274/TurkJOrthod.2022.2022.92
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1183817
dc.identifier.urihttps://hdl.handle.net/11480/16392
dc.identifier.volume36
dc.identifier.wosWOS:001026258500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Orthodontics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectFunctional mandibular advancement
dc.subjectgrape -seed extract
dc.subjectlaser therapy
dc.subjectmandibular condyle
dc.subjectstem cell therapy
dc.titleThe Condylar Effects of Mesenchymal Stem Cells, Low-Level Laser Therapy and Grape Seed Extract on Functional Mandibular Advancement of the Rat Mandible
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu