The effects of acrylamide and vitamin E administration during pregnancy on adults’ ovarian tissue: An experimental study

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dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorTürköz, Yusuf
dc.contributor.authorBağ, Harika Gözde Gözükara
dc.contributor.authorSelamoğlu, Zeliha
dc.date.accessioned2024-11-07T13:19:28Z
dc.date.available2024-11-07T13:19:28Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: The aim of the present study is to investigate the effects on ovarian tissues of adult female rats, which were the offspring ofrats administered acrylamide (AA) and vitamin E during pregnancy.Material and Methods: Thirty rats were divided into 5 groups of 6 pregnant rats, as the Control, Corn Oil, Vitamin E, AA, Vitamin E +AA groups. The births were monitored on the 21st day to select the female rats. The selected female rats were decapitated at the endof the 8th week and their ovarian tissues were removed under anesthesia malondialdehyde (MDA), reduced glutathione (GSH), totalantioxidant capacity (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT)and nitric oxide (NO) levels were examined.Results: Administration of AA during pregnancy caused an increase in MDA, TOS, OSI and NO levels and a decrease in GSH, SOD, CATand TAS levels in the ovarian tissues of the rats when compared to the control group. It was determined that vitamin E administrationcaused an increase in GSH, SOD, CAT and TAS levels in ovarian tissues, compared to all other groups (P <0.05).Conclusion: Exposure to food-induced AA toxicity increases each day and the parallel increase in infertility suggests that it could berelated to AA toxicity. Although vitamin E is capable to exert a protective effect against AA toxicity through increasing the antioxidantcapacity of ovarian tissue, there is certain necessity for further studies.
dc.identifier.doi10.5455/annalsmedres.2019.06.356
dc.identifier.endpage1860
dc.identifier.issn2636-7688
dc.identifier.issue9
dc.identifier.startpage1856
dc.identifier.trdizinid318186
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2019.06.356
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/318186
dc.identifier.urihttps://hdl.handle.net/11480/13144
dc.identifier.volume26
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectTıbbi
dc.subjectÇevre Bilimleri
dc.titleThe effects of acrylamide and vitamin E administration during pregnancy on adults’ ovarian tissue: An experimental study
dc.typeArticle

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