Poly(acrylic acid)-b-Poly(vinylamine) Copolymer: Decoration with Silver Nanoparticles, Antibacterial Properties, Quorum Sensing Activity, and Cytotoxicity on Breast Cancer and Fibroblast Cell Lines

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dc.authoridSutekin, S. Duygu/0000-0002-4605-1116
dc.authoridBarsbay, Murat/0000-0003-0788-4446
dc.contributor.authorGhaffarlou, Mohammadreza
dc.contributor.authorSutekin, S. Duygu
dc.contributor.authorHammamchi, Hamideh
dc.contributor.authorIlk, Sedef
dc.contributor.authorGuven, Olgun
dc.contributor.authorBarsbay, Murat
dc.date.accessioned2024-11-07T13:34:08Z
dc.date.available2024-11-07T13:34:08Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAn elegant integration of primary amine-bearing segments into the acrylic acid-containing blocks and the subsequent addition of silver nanoparticles (Ag NPs) to this double hydrophilic block copolymer endowed the resulting well-defined self-assembled construct with promising antimicrobial and anti-quorum sensing activity and high cytotoxicity against breast cancer cells. Poly(N- vinylformamide) (PNVF), precursor of amphoteric poly(vinyl amine) (PVAm), was chain-extended from pH-responsive poly(acrylic acid) (PAA) macro-chain transfer agent synthesized via reversible addition-fragmentation chain transfer polymerization by the interchange of xanthates (RAFT/MADIX). PAA-b-PNVF block copolymers with molecular weights in the range of 12500-21800 Da and dispersities between 1.29 and 1.44 were characterized by FTIR, elemental analysis,H- 1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and size exclusion chromatography (SEC). PAA-b-PVAm copolymer was obtained by hydrolysis of the PNVF block. The decoration of PAA-b-PVAm with monodisperse Ag NPs to yield AgNPs@PAA-b-PVAm proceeded through a simple and green approach by amine-induced reduction of Ag ions in aqueous media. The formation of AgNPs@PAA-b-PVAm was characterized by UV/vis spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and atomic force microscopy (AFM). AgNPs@PAA-b-PVAm displayed superior antimicrobial and anti QS activity. The cell proliferation was tested with an MTT assay on L929 and MCF-7 cell lines. Both the AgNP-decorated and the bare copolymer showed significantly higher cytotoxicity on cancer cells compared to healthy ones.
dc.identifier.doi10.1021/acsapm.2c00906
dc.identifier.endpage7281
dc.identifier.issn2637-6105
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85138610040
dc.identifier.scopusqualityQ1
dc.identifier.startpage7268
dc.identifier.urihttps://doi.org/10.1021/acsapm.2c00906
dc.identifier.urihttps://hdl.handle.net/11480/15820
dc.identifier.volume4
dc.identifier.wosWOS:000856649400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Applied Polymer Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectpoly(vinyl amine)
dc.subjectpoly(acrylic acid)
dc.subjectblock copolymer
dc.subjectsilver nanoparticle
dc.subjecthybrid nanoconstructs
dc.subjectantibacterial
dc.subjectanti-quorum-sensing
dc.subjectcytotoxicity
dc.titlePoly(acrylic acid)-b-Poly(vinylamine) Copolymer: Decoration with Silver Nanoparticles, Antibacterial Properties, Quorum Sensing Activity, and Cytotoxicity on Breast Cancer and Fibroblast Cell Lines
dc.typeArticle

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