The Effect of Antibiotic Resistance and Inappropriate Empirical Antibiotic Therapy on 3-Day and 28-Day Mortality in Bacteremic Patients in the Intensive Care Unit: 5-Year Retrospective Analysis

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dc.authoridodemis, ilker/0000-0003-2638-0163
dc.authoridARSLAN GULEN, TUGBA/0000-0001-5706-9824
dc.contributor.authorOdemis, Ilker
dc.contributor.authorArslan Gulen, Tugba
dc.date.accessioned2024-11-07T13:24:54Z
dc.date.available2024-11-07T13:24:54Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: The aim of this study was to examine the effects of antibiotic resistance, empirical antibiotic therapy, and comorbid diseases on 3 -day and 28 -day mortality in patients with bloodstream infections. Material and Methods: Files of the patients with positive blood cultures results, between January 1(st), 2015, and January 1(st), 2020 were analyzed retrospectively. The primary outcome was 3 -day mortality and the secondary outcome was 28 -day mortality. Results: A total of 515 patients, 208 (40.4%) female and 307 (59.6%) male, were included in the study. The median age of the patients was 73 (range, 18-95) years. Vancomycin resistance was detected in 8 (3.4%) of 233 gram -positive bacteria. Third -generation cephalosporin, meropenem, and colistin resistance rates of the 282 gram -negative bacteria were found to be 72.7% (n=205), 53.2% (n=150), and 9.9% (n=28), respectively. The 3 -day and 28 -day mortality rates were 14.4% (n=74) and 64.3% (n=331), respectively. Charlson comorbidity index score (CCIS) (p=0.001) and acute physiology and chronic health evaluation (APACHE) II score (p=0.019) were found to be risk factors for 3 -day mortality. Risk factors for 28 -day mortality were; age (p<0.001), CCIS (p<0.001), APACHE II score (p=0.001), chronic obstructive pulmonary disease (p=0.007), hospital -acquired infection (p=0.033), and inappropriate antibiotic therapy (p<0.001). Conclusion: There was no association between antibiotic resistance and mortality, but inappropriate antibiotic treatment was found to increase the risk of 28 -day mortality. In addition, since high CCIS and APACHE II scores increase the risk of both 3 -day and 28 -day mortality, we think that considering these scoring systems will reduce the risk of mortality.
dc.identifier.doi10.18678/dtfd.1069393
dc.identifier.endpage192
dc.identifier.issn1307-671X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85136912113
dc.identifier.scopusqualityQ4
dc.identifier.startpage187
dc.identifier.trdizinid1115677
dc.identifier.urihttps://doi.org/10.18678/dtfd.1069393
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1115677
dc.identifier.urihttps://hdl.handle.net/11480/14368
dc.identifier.volume24
dc.identifier.wosWOS:001207163500017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDuzce Univ, Fac Medicine
dc.relation.ispartofDuzce Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectMortality
dc.subjectsepsis
dc.subjectcritical care
dc.subjectbacteremia
dc.subjectantibiotic
dc.subjectresistance
dc.titleThe Effect of Antibiotic Resistance and Inappropriate Empirical Antibiotic Therapy on 3-Day and 28-Day Mortality in Bacteremic Patients in the Intensive Care Unit: 5-Year Retrospective Analysis
dc.title.alternativeYoğun Bakım Ünitesindeki Bakteriyemik Hastalarda Antibiyotik Direncinin ve Uygunsuz Ampirik Antibiyotik Tedavisinin 3 Günlük ve 28 Günlük Mortalite Üzerine Etkisi: 5 Yıllık Retrospektif Analiz
dc.typeArticle

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