A detailed in-silico analysis of potential gastric cancer molecular marker genes in the literature
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Inderscience Enterprises Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Genes found extremely important for the diagnosis and prognosis of Gastric Cancer (GC) in the literature between 2015 and 2020 were analysed in detail by in-silico methods. Thereby, broadly-based analysis of the genes was performed for future studies of GC. For this purpose, expression, pathological stage, Overall Survival (OS) and Disease Free Survival (DFS) plots were carried out with GEPIA web tool. PolyPhen-2 and SNAP tools were used to detect pathogenic impact of the mutations. As a result, COL10A1, SOX9, MTBP, CCL5, PSMB8 and PBK genes were found significant to distinguish individuals with GC from healthy individuals. PCDH9 and HGF genes were found significant for both OS and DFS. METTL3, COL10A1, USP3, CCL5, IMP3, CXCR6, PBK, HGF, MRC1, CD163, SSP1 genes were found correlated with the stage of GC. Effect of the mutations of PCDH9 and HGF genes, especially on the Kringle domain of HGF gene, were found pathogenic.
Açıklama
Anahtar Kelimeler
gastric cancer, molecular marker, PCDH9, HGF, Kringle domain, SOX9, CCL5, PSMB8, PBK
Kaynak
International Journal of Data Mining and Bioinformatics
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
25
Sayı
3-4
