A detailed in-silico analysis of potential gastric cancer molecular marker genes in the literature

Basit Öğe Kaydı
dc.contributor.authorAktas, Sedef Hande
dc.contributor.authorAkin-Bali, Dilara Fatma
dc.contributor.authorYazici, Ozan
dc.date.accessioned2024-11-07T13:34:31Z
dc.date.available2024-11-07T13:34:31Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractGenes found extremely important for the diagnosis and prognosis of Gastric Cancer (GC) in the literature between 2015 and 2020 were analysed in detail by in-silico methods. Thereby, broadly-based analysis of the genes was performed for future studies of GC. For this purpose, expression, pathological stage, Overall Survival (OS) and Disease Free Survival (DFS) plots were carried out with GEPIA web tool. PolyPhen-2 and SNAP tools were used to detect pathogenic impact of the mutations. As a result, COL10A1, SOX9, MTBP, CCL5, PSMB8 and PBK genes were found significant to distinguish individuals with GC from healthy individuals. PCDH9 and HGF genes were found significant for both OS and DFS. METTL3, COL10A1, USP3, CCL5, IMP3, CXCR6, PBK, HGF, MRC1, CD163, SSP1 genes were found correlated with the stage of GC. Effect of the mutations of PCDH9 and HGF genes, especially on the Kringle domain of HGF gene, were found pathogenic.
dc.identifier.doi10.1504/IJDMB.2021.122861
dc.identifier.endpage215
dc.identifier.issn1748-5673
dc.identifier.issn1748-5681
dc.identifier.issue3-4
dc.identifier.scopus2-s2.0-85130526241
dc.identifier.scopusqualityQ4
dc.identifier.startpage201
dc.identifier.urihttps://doi.org/10.1504/IJDMB.2021.122861
dc.identifier.urihttps://hdl.handle.net/11480/16028
dc.identifier.volume25
dc.identifier.wosWOS:000795159900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInderscience Enterprises Ltd
dc.relation.ispartofInternational Journal of Data Mining and Bioinformatics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectgastric cancer
dc.subjectmolecular marker
dc.subjectPCDH9
dc.subjectHGF
dc.subjectKringle domain
dc.subjectSOX9
dc.subjectCCL5
dc.subjectPSMB8
dc.subjectPBK
dc.titleA detailed in-silico analysis of potential gastric cancer molecular marker genes in the literature
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu