Propolis reduces oxidative stress in L-NAME- induced hypertension rats
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Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by N-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40mg kg(-1), intraperitoneally) for 15days to produce hypertension and propolis (200mg kg(-1), by gavage) during the last 5days. MDA level in l-NAME-treated group significantly increased compared with control group (P<0.01). MDA level of l-NAME+propolis-treated rats significantly reduced (P<0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P<0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME+propolis group compared with the l-NAME-treated group (P>0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system. Copyright (c) 2013 John Wiley & Sons, Ltd.
Description
Keywords
Catalase, l-NAME, malondialdehyde, nitric oxide, oxidative stress, propolis
Journal or Series
CELL BIOCHEMISTRY AND FUNCTION
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
32
Issue
2
