Propolis reduces oxidative stress in L-NAME- induced hypertension rats
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by N-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40mg kg(-1), intraperitoneally) for 15days to produce hypertension and propolis (200mg kg(-1), by gavage) during the last 5days. MDA level in l-NAME-treated group significantly increased compared with control group (P<0.01). MDA level of l-NAME+propolis-treated rats significantly reduced (P<0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P<0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME+propolis group compared with the l-NAME-treated group (P>0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system. Copyright (c) 2013 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
Catalase, l-NAME, malondialdehyde, nitric oxide, oxidative stress, propolis
Kaynak
CELL BIOCHEMISTRY AND FUNCTION
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
32
Sayı
2
