Propolis reduces oxidative stress in L-NAME- induced hypertension rats

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dc.contributor.authorTalas, Zeliha Selamoglu
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2014
dc.departmentNiğde ÖHÜ
dc.description.abstractThe inhibition in the synthesis or bioavailability of nitric oxide (NO) has an important role in progress of hypertension. The blocking of nitric oxide synthase activity may cause vasoconstriction with the formation of reactive oxygen species (ROS). Propolis is a resinous substance collected by honey bees from various plants. Propolis has biological and pharmacological properties. The aim of this study was to examine the effect of propolis on catalase (CAT) activity, malondialdehyde (MDA) and NO levels in the testis tissues of hypertensive rats by N-nitro-l-arginine methyl ester (l-NAME). Rats have received nitric oxide synthase inhibitor (l-NAME, 40mg kg(-1), intraperitoneally) for 15days to produce hypertension and propolis (200mg kg(-1), by gavage) during the last 5days. MDA level in l-NAME-treated group significantly increased compared with control group (P<0.01). MDA level of l-NAME+propolis-treated rats significantly reduced (P<0.01) compared with l-NAME-treated group. CAT activity and NO level significantly reduced (P<0.01) in l-NAME group compared with control group. There were no statistically significant increases in the CAT activity and NO level of the l-NAME+propolis group compared with the l-NAME-treated group (P>0.01). These results suggest that propolis changes CAT activity, NO and MDA levels in testis of l-NAME-treated animals, and so it may modulate the antioxidant system. Copyright (c) 2013 John Wiley & Sons, Ltd.
dc.description.sponsorshipNigde University Research Fund [BAP 2008/25]
dc.description.sponsorshipThe Nigde University Research Fund (grant no. BAP 2008/25) is gratefully acknowledged for supporting this work. The authors thank Dr. Ilknur Ozdemir and Dr. Osman Ciftci at Inonu University in Turkey for letting them use their laboratory and Dr. Engin Sahna at Firat University in Turkey for helping in animal research.
dc.identifier.doi10.1002/cbf.2986
dc.identifier.endpage154
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2
dc.identifier.pmid23788129
dc.identifier.scopus2-s2.0-84895545062
dc.identifier.scopusqualityQ2
dc.identifier.startpage150
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.2986
dc.identifier.urihttps://hdl.handle.net/11480/4194
dc.identifier.volume32
dc.identifier.wosWOS:000332988000004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTalas, Zeliha Selamoglu
dc.language.isoen
dc.publisherWILEY
dc.relation.ispartofCELL BIOCHEMISTRY AND FUNCTION
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCatalase
dc.subjectl-NAME
dc.subjectmalondialdehyde
dc.subjectnitric oxide
dc.subjectoxidative stress
dc.subjectpropolis
dc.titlePropolis reduces oxidative stress in L-NAME- induced hypertension rats
dc.typeArticle

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