The MNS16A VNTR polymorphism of the TERT gene in bladder cancer

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dc.authoridBingol, Gunsel/0000-0001-9834-0019
dc.contributor.authorDiler, Songul Budak
dc.contributor.authorPolat, Fikriye
dc.contributor.authorBingol, Gunsel
dc.date.accessioned2024-11-07T13:32:19Z
dc.date.available2024-11-07T13:32:19Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Bladder cancer (BC) is a complex disease that has a high morbidity rate. The MNS16A polymorphism in the TERT gene has been indicated to play a role in the presence of various cancer types and multiple tumor populations. In the present study, our goal was to investigate whether the MNS16A (VNTRs) in the TERT gene was associated with bladder cancer. Material and methods: A total of 70 patients with BC and 120 normal controls were included in the study. The MNS16A (VNTRs) in the TERT gene was amplified using polymerase chain reaction (PCR). The PCR products were visualized on 3% high resolution agarose gel and under a UV light. Results: The MNS16A VNTR-302 allele was found to be the most common allele in both, the patient group (64%) and the control group (62%). The second most common allele was the VNTR-243 allele that occurred at a frequency of around 34% in BC patients and 33% in the controls. VNTR-333 (patient group, 1%; control group, 3%) and VNTR-274 (patient group, 2%; control group, 1%) alleles were reported as the least common alleles in this study. Conclusion: When comparing the frequencies of genetic variants between cases and controls, we observed that our findings did not support the hypothesis that the MNS16A VNTR polymorphism of the TERT gene might regulate cancer susceptibility.
dc.identifier.doi10.5152/tud.2019.19005
dc.identifier.endpage49
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue1
dc.identifier.pmid31905123
dc.identifier.scopus2-s2.0-85077841475
dc.identifier.scopusqualityQ3
dc.identifier.startpage44
dc.identifier.trdizinid365026
dc.identifier.urihttps://doi.org/10.5152/tud.2019.19005
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/365026
dc.identifier.urihttps://hdl.handle.net/11480/15352
dc.identifier.volume46
dc.identifier.wosWOS:000505165000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBladder cancer
dc.subjectMNS16A (VNTR) polymorphism
dc.subjectTERT gene
dc.titleThe MNS16A VNTR polymorphism of the TERT gene in bladder cancer
dc.typeArticle

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