Investigation of miR-144-3p expression levels in HbSS cases with high and normal HbF

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dc.authoridGuzelgul, Figen/0000-0002-2796-9511
dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.contributor.authorGuzelgul, Figen
dc.contributor.authorSeydel, Gonul Seyda
dc.contributor.authorAlparslan, Zeliha Nazan
dc.contributor.authorAksoy, Kiymet
dc.date.accessioned2024-11-07T13:32:58Z
dc.date.available2024-11-07T13:32:58Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Sickle cell anemia (HbSS) is a hereditary blood disease that affects millions of people worldwide. Increased the HbF levels affects the clinical course of HbSS positively. The aim of this study was to investigate the association between miR-144-3p and HbSS. Materials and methods: In this study 84 cases (44 HbSS/HbS combination and 40 HbAA) were performed. The expression of miR-144-3p was determined by RT-PCR. Statistical analysis was performed by the Mann-Whitney U test (SPSS 20.00 for Windows and p<0.005). Results: The miR-144-3p expression levels were higher in the HbSS cases (p <= 0.001). Additionally, it was determined that the expression of miR-144-3p was higher in the cases with HbF<3 (p=0.043). Discussion: In our study, the increase in the miR-144-3p levels in low HbF levels may be associated with the severity of the disease. Conclusion: Considering these results, suppressing miR144-3p may be considered as a new treatment option in HbSS.
dc.description.sponsorshipCukurova University Research Fund, Adana, Turkey [TF2012D7, TF2012BAP18, TF2012BAP20, TF2012BAP22]
dc.description.sponsorshipThis work was supported by Cukurova University Research Fund, Adana, Turkey, project no. TF2012D7, TF2012BAP18, TF2012BAP20 and TF2012BAP22.
dc.identifier.doi10.1515/tjb-2019-0496
dc.identifier.endpage56
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85103467062
dc.identifier.scopusqualityQ4
dc.identifier.startpage51
dc.identifier.trdizinid492705
dc.identifier.urihttps://doi.org/10.1515/tjb-2019-0496
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/492705
dc.identifier.urihttps://hdl.handle.net/11480/15716
dc.identifier.volume46
dc.identifier.wosWOS:000625120300008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectfetal hemoglobin
dc.subjectmiRNA
dc.subjectsickle cell anemia
dc.titleInvestigation of miR-144-3p expression levels in HbSS cases with high and normal HbF
dc.typeArticle

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