How does tranexamic acid affect blood transfusion and bleeding amount in pelvis-acetabulum fractures treated with open reduction and internal fixation?

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dc.authoriddemir, ibrahim halil/0000-0002-7572-7285
dc.contributor.authorTekin, Sezgin Bahadir
dc.contributor.authorDemir, Ibrahim Halil
dc.contributor.authorBozgeyik, Bahri
dc.contributor.authorMert, Ahmet
dc.date.accessioned2024-11-07T13:34:44Z
dc.date.available2024-11-07T13:34:44Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBACKGROUND: This study aimed to investigate intravenous tranexamic acid's (TA) effect on blood loss and transfusion ratios in pelvis-acetabulum fractures treated with open reduction and internal fixation.METHODS: Patients who underwent open reduction and internal fixation due to pelvis-acetabulum fractures between January 2017 and January 2019 constituted this study's target population. After applying inclusion and exclusion criteria, patients were divided into two groups: Those who were perioperatively given 15 mg/kg TA (i.e., Group 1) and those who were not (i.e., Group 2). Data including age, gender, mechanism of injury, fracture type, presence or absence of additional injuries, the time interval between admission and surgery, incision site, pre-operative and post-operative hemoglobin levels, intraoperative estimated blood loss (EBL), number of blood units transfused, and complications were recorded. Two groups were compared regarding these parameters.RESULTS: The study cohort included 58 patients. There were 30 patients in Group 1 and 28 patients in Group 2. Our analysis revealed that the number of blood units transfused was significantly higher in Group 2 than Group 1 (p=0.016). However, there was no significant difference between the two groups regarding intraoperative EBL, pre-operative and post-operative hemoglobin levels, and the time interval between admission and surgery.CONCLUSION: Administration of intravenous TA reduces blood transfusion requirement in patients with pelvis-acetabulum fractures treated with open reduction and internal fixation. This approach can prevent potential blood transfusion-related complications.
dc.identifier.doi10.14744/tjtes.2021.45843
dc.identifier.endpage1327
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue9
dc.identifier.pmid36043923
dc.identifier.scopus2-s2.0-85137138655
dc.identifier.scopusqualityQ2
dc.identifier.startpage1323
dc.identifier.trdizinid1179367
dc.identifier.urihttps://doi.org/10.14744/tjtes.2021.45843
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1179367
dc.identifier.urihttps://hdl.handle.net/11480/16145
dc.identifier.volume28
dc.identifier.wosWOS:000863207500016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAcetabulum
dc.subjectblood transfusion
dc.subjectpelvis
dc.subjecttranexamic acid
dc.subjecttrauma
dc.titleHow does tranexamic acid affect blood transfusion and bleeding amount in pelvis-acetabulum fractures treated with open reduction and internal fixation?
dc.title.alternativeAçık redüksiyon ve internal fiksasyonla tedavi edilen pelvis-asetabulum kırıklarında traneksamik asit kan transfüzyonu ve kanama miktarlarını nasıl etkiler?
dc.typeArticle

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