The effect of letrozole on liver function and some biochemical parameters in rats

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dc.contributor.authorDolanbay, Turgut
dc.contributor.authorMakav, Mustafa
dc.contributor.authorVural, Abdussamed
dc.contributor.authorCumaoğlu, Mustafa Oğuz
dc.contributor.authorYuceer, Ömer
dc.contributor.authorBaşer, Lale
dc.contributor.authorMetin, Hatice Tetik
dc.date.accessioned2024-11-07T13:19:03Z
dc.date.available2024-11-07T13:19:03Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractLetrozole (LTZ), is an aromatase inhibitor, that has been widely used in a variety of diseases such as polycystic ovary syndrome, endometriosis, and breast cancer. LTZ is received via the oral route and metabolized in the liver. Therefore, LTZ may have toxic effects like other drugs metabolized in the liver. Based on this, our study aimed to investigate the effect of LTZ on liver function and biochemical parameters. For this purpose, 16 Wistar albino female rats were divided into two groups (n=8): Control and LTZ respectively. The rats in the letrozole group were administered with 2 mL/kg LTZ by oral gavage once a day for 21 days. The Control group received the vehicle once a day for 21 days. Blood samples were collected on the 22nd day of the experiment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), albumin (ALB), alkaline phosphatase (ALP), direct bilirubin and total bilirubin were measured. Biochemical analysis indicated that ALT, AST, LDH, ALP, and total bilirubin levels were significantly higher in the LTZ administrated group compared to the Control. ALB levels decreased in the LTZ group. In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver. We suggested that long-term LTZ administrated patients should be under control against liver damage and may have liver supporting adjuvant therapies for robust liver functions.
dc.identifier.doi10.31797/vetbio.1451147
dc.identifier.endpage72
dc.identifier.issn2548-1150
dc.identifier.issue1
dc.identifier.startpage65
dc.identifier.trdizinid1233440
dc.identifier.urihttps://doi.org/10.31797/vetbio.1451147
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1233440
dc.identifier.urihttps://hdl.handle.net/11480/12853
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of advances in vetbio science and techniques
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectKimya
dc.subjectTıbbi
dc.subjectOnkoloji
dc.subjectVeterinerlik
dc.subjectAlbumin
dc.subjecthepatotoxicity
dc.subjectletrozole
dc.subjectliver function tests
dc.titleThe effect of letrozole on liver function and some biochemical parameters in rats
dc.typeArticle

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