Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKD-EPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study

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dc.contributor.authorUcucu, Suheyl
dc.contributor.authorAyan, Durmus
dc.contributor.authorSerin, Erdinc
dc.date.accessioned2024-11-07T13:32:03Z
dc.date.available2024-11-07T13:32:03Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: Serum cystatin C level is a specific marker to estimate the glomerular filtration rate (GFR). Due to this specificity, we assume that GFR estimations based on cystatin C have higher diagnostic performances than GFR estimations using other biomarkers. In this study, we aimed to compared the diagnostic performances of CKDEPI cystatin C equation, CKD-EPI creatinine equation and 24-hour creatinine clearance to estimate GFR. Materials and Methods: A total of 130 participants who consisting of 101 acute and chronic renal disease patients and 29 healthy volunteers, who applied to the Nephrology Clinic, have been included in our study. Their urine creatinine levels and serum creatinine levels were measured by the colorimetric-Jaffe method, and cystatin C was by the nephelometric method. Results: There was a statistically significant relationship between CKD-EPI cystatin C, between CKD-EPI creatinine and standard creatinine clearance. The Area Under the Receiver Operating Characteristics curve (AUROC) was found to be 1, 0.995, and 0.954 respectively. Conclusion: According to the results, we think that serum cystatin C levels will present earlier findings in GFR decrease and may be a more effective marker than serum creatinine and standard creatinine clearance in the early period.
dc.identifier.doi10.17826/cumj.783433
dc.identifier.endpage10
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid428922
dc.identifier.urihttps://doi.org/10.17826/cumj.783433
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/428922
dc.identifier.urihttps://hdl.handle.net/11480/15186
dc.identifier.volume46
dc.identifier.wosWOS:000632797000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectCystatin C
dc.subjectCKD-EPI
dc.subjectGlomerular Filtration Rate
dc.subjectcreatinine
dc.subjectkidney failure
dc.titleComparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKD-EPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study
dc.typeArticle

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