Bioinformatic Investigation of Genetic Changes in Paraoxonase Genes in Breast Cancer and Breast Cancer Subtypes

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dc.authoridGul, Mehmet Ali/0000-0002-5849-0116
dc.contributor.authorAyan, Durmus
dc.contributor.authorGul, Mehmet Ali
dc.contributor.authorKarabay, Umut
dc.contributor.authorBulut, Seyyid Mehmet
dc.date.accessioned2024-11-07T13:32:33Z
dc.date.available2024-11-07T13:32:33Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Among women, breast cancer (BC) is the most prevalent form of cancer. Many molecular targets have been discovered for BC prognosis and treatment. However, new markers still need to be identified, as cancer pathogenesis is triggered by different mechanisms. The aim of this study was to examine the changes in the paraoxonase genes ( PON1 , PON2 , and PON 3 ) involved in the pathogenesis of BC. Materials and Methods: The characteristics of the mutations were evaluated with the Cbioportal database. Kaplan-Meier Plot evaluated recurrence-free survival (RFS). The UALCAN database determined the promoter methylation. Gene expression was evaluated by GEPIA2.0 database. Results: PON1 harbored the most mutations. There was a significant decrease in PON3 expression levels in BC samples compared with healthy samples. PON1 and PON2 expression levels did not differ between BC tissue and normal adjacent tissue. Elevated expression levels of PON1 and PON2 genes were correlated with longer RFS, whereas reduced expression of the PON2 gene showed an association with longer RFS. Moreover, the promoter regions of PON1 and PON 3 were found to be hypermethylated, while the promoter region of PON 2 was found to be hypomethylated. The PON3 promoter region was significantly hypermethylated in luminal and human epidermal growth factor receptor 2 (HER2) + BC subtypes. However, the PON3 promoter region was significantly hypomethylated in the triple negative breast cancer (TNBC) subtype. Conclusion: These results suggest that methylation and expression status of PON3 in BC and BC subtypes (TNBC, luminal and HER2) may indicate a poor prognosis. The PON3 gene could be a negative prognostic marker in BC. However, the results should be supported by prospective studies.
dc.identifier.doi10.4274/ejbh.galenos.2024.2024-3-7
dc.identifier.endpage184
dc.identifier.issn2587-0831
dc.identifier.issue3
dc.identifier.pmid39257009
dc.identifier.scopus2-s2.0-85201466799
dc.identifier.scopusqualityN/A
dc.identifier.startpage178
dc.identifier.trdizinid1276703
dc.identifier.urihttps://doi.org/10.4274/ejbh.galenos.2024.2024-3-7
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1276703
dc.identifier.urihttps://hdl.handle.net/11480/15461
dc.identifier.volume20
dc.identifier.wosWOS:001272819100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofEuropean Journal of Breast Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBreast cancer
dc.subjectparaoxonase
dc.subjectbioinformatics
dc.titleBioinformatic Investigation of Genetic Changes in Paraoxonase Genes in Breast Cancer and Breast Cancer Subtypes
dc.typeArticle

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