The Inhibitory Effect of Capparis Ovata Polysaccharides on Cultured Pterygium Fibroblasts

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dc.contributor.authorKüçük, Erkut
dc.contributor.authorZor, Kürşat
dc.contributor.authorAydemir, Işıl
dc.contributor.authorÖzkan, Oktay
dc.date.accessioned2024-11-07T13:15:52Z
dc.date.available2024-11-07T13:15:52Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives: Pterygium recurrence after removal surgery is an important problem. Polysaccharides obtained from Capparis species have been shown to possess various biological properties, including anti-tumor activity. This study was aninvestigation of the effect of Capparis ovata polysaccharides on cultured pterygium fibroblasts and a comparison with the effects of mitomycin C (MMC).Methods: Pterygium tissue samples were obtained during excision surgery from 3 patients with primary pterygium, and fibroblasts were isolated. Pterygium fibroblast cultures and L929 cell cultures were treated with different concentrations of MMC and Capparis ovata polysaccharides. Cell proliferation and migration were evaluated.Results: An MTT assay revealed that cell viability decreased with increasing concentrations of Capparis ovata polysaccharides in both cell types. MMC also inhibited the proliferation of both cell types. A scratch-wound assay indicated thatboth Capparis ovata polysaccharides and MMC molecules reduced proliferation and migration in the pterygium fibroblasts and L929 cells.Conclusion: The in vitro Capparis ovata polysaccharide inhibition of proliferation and migration of pterygium fibroblasts was similar to that of MMC. The results of this study suggested that Capparis ovata polysaccharides may be a valuable candidate drug to treat pterygium.
dc.identifier.doi10.14744/bej.2021.60352
dc.identifier.endpage6
dc.identifier.issn2459-1777
dc.identifier.issn2587-0394
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid427426
dc.identifier.urihttps://doi.org/10.14744/bej.2021.60352
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/427426
dc.identifier.urihttps://hdl.handle.net/11480/11902
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofBEYOGLU EYE JOURNAL
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectBiyoloji
dc.subjectGöz Hastalıkları
dc.titleThe Inhibitory Effect of Capparis Ovata Polysaccharides on Cultured Pterygium Fibroblasts
dc.typeArticle

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