Neuroprotection against CCl 4 induced brain damage with crocin in Wistar rats

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dc.contributor.authorAltinoz E.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorAksungur Z.
dc.contributor.authorGul S.
dc.contributor.authorBag H.G.
dc.contributor.authorTurkoz Y.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractOwing to its lipophilic property, carbon tetrachloride (CCl 4 ) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl 4 . Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl 4 and CCl 4 + crocin. CCl 4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl 4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl 4 induced brain damage by preventing oxidative stress. © 2018, © 2018 The Biological Stain Commission.
dc.identifier.doi10.1080/10520295.2018.1519725
dc.identifier.endpage631
dc.identifier.issn1052-0295
dc.identifier.issue8
dc.identifier.pmid30273072
dc.identifier.scopus2-s2.0-85054386999
dc.identifier.scopusqualityQ2
dc.identifier.startpage623
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2018.1519725
dc.identifier.urihttps://hdl.handle.net/11480/1583
dc.identifier.volume93
dc.identifier.wosWOS:000451027400011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain damage
dc.subjectcarbon tetrachloride
dc.subjectcatalase
dc.subjectcrocin
dc.subjectglutathione
dc.subjectmalondialdehyde
dc.subjectoxidative stress
dc.titleNeuroprotection against CCl 4 induced brain damage with crocin in Wistar rats
dc.typeArticle

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