Neuroprotection against CCl 4 induced brain damage with crocin in Wistar rats

Küçük Resim Yok

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Taylor and Francis Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Owing to its lipophilic property, carbon tetrachloride (CCl 4 ) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl 4 . Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl 4 and CCl 4 + crocin. CCl 4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl 4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl 4 induced brain damage by preventing oxidative stress. © 2018, © 2018 The Biological Stain Commission.

Açıklama

Anahtar Kelimeler

Brain damage, carbon tetrachloride, catalase, crocin, glutathione, malondialdehyde, oxidative stress

Kaynak

Biotechnic and Histochemistry

WoS Q Değeri

Q4

Scopus Q Değeri

Q2

Cilt

93

Sayı

8

Künye