Investigation of Left Atrial Spontaneous Echo Contrast as a Marker Indicating Ineffective Anticoagulation in Patients with Mitral Valve Replacement Receiving Warfarin

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dc.contributor.authorGunturk, Ertugrul Emre
dc.contributor.authorDemirbas, Melih
dc.contributor.authorDogan, Yasemin
dc.contributor.authorDogan, Selcuk
dc.contributor.authorGunturk, Inayet
dc.date.accessioned2024-11-07T13:15:53Z
dc.date.available2024-11-07T13:15:53Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives: This study aimed to evaluate predictive role of left atrial (LA) spontaneous echo contrast (SEC) for ineffec-tive anticoagulation by assessing time in therapeutic range (TTR) via international normalized ratio (INR) monitoring in patients with mitral valve replacement (MVR) and to determine its relationship with increased thromboembolic events.Methods: The study included patients with mechanical MVR. TTR was estimated using serial INR measurements. On transthoracic echocardiography, left ventricular end-systolic/end-diastolic diameters, LA diameter, ejection fraction were measured, and the presence of SEC was determined.Results: The study included 65 patients with MVR (30 with LA SEC) and 35 without LA SEC. There was a trend for higher rates of cerebrovascular event in the patients with SEC than in those without (30% vs. 14.3%, p=0.046). The LA diameter was higher and the TTR was lower in the patients with SEC than in those without. There was a significant negative cor-relation between TTR and thromboembolic events. Multivariable logistic regression analysis revealed the TTR and LA diameter as independent factors affecting SEC.Conclusion: In patients with MVR, low TTR and enlarged left atrium were independent predictors for future throm-boembolic events. Monitoring INR is important to achieve higher TTR in the presence of LA SEC.
dc.identifier.doi10.14744/ejmi.2019.29093
dc.identifier.endpage168
dc.identifier.issn2602-3164
dc.identifier.issue2
dc.identifier.startpage163
dc.identifier.trdizinid371871
dc.identifier.urihttps://doi.org/10.14744/ejmi.2019.29093
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/371871
dc.identifier.urihttps://hdl.handle.net/11480/11905
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEurasian Journal of Medical Investigation
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241107
dc.subjectGenel ve Dahili Tıp
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleInvestigation of Left Atrial Spontaneous Echo Contrast as a Marker Indicating Ineffective Anticoagulation in Patients with Mitral Valve Replacement Receiving Warfarin
dc.typeArticle

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